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. 2023 May 25;17:1180798. doi: 10.3389/fncel.2023.1180798

Figure 5.

Figure 5

cAMP does not modulate OSN responses in a long exposure regime. (A) Schema of the cAMP pathway. Adenyl cyclase (AC) catalyzes the conversion of ATP into cAMP, which is hypothesized to induce Orco channel opening through direct binding. Various pharmacons (blue) can be used to modulate this pathway. (B) Time course of OSN responses to VUAA1 in the absence (first response) and presence (second response) of 10 μM 8Br-cAMP, a cell-permeable, hydrolysis-resistant analog of cAMP. The bar plot indicates the mean total response amplitude for each response ± SEM. (C) Time course of OSN responses in the absence (first response) and presence (second response) of 200 μM 8Br-cAMP, a cell-permeable, hydrolysis-resistant analog of cAMP. The bar plot indicates the mean total response amplitude for each response ± SEM. (D) Time course of OSN responses in the absence (first response) and presence (second response) of 10 μM forskolin, a potent adenyl cyclase agonist (activator). The bar plot indicates the mean total response amplitude for each response ± SEM. Peak response latencies are reported in parentheses in all bar plots.