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. 2023 May 25;17:1189489. doi: 10.3389/fnbeh.2023.1189489

Figure 3.

Figure 3

Pain-related behavior evaluations of female LAS model mice. (A) Time course showing the changes in 50% paw withdrawal threshold (PWT) of the ipsilateral hind paw of female sham and LAS model mice from days 0 to 21. (B) Area under the curve (AUC) analysis of corresponding traces in (A). (C, D) Paw withdrawal frequency (PWF) of the ipsilateral hind paw of female sham and LAS model mice in response to specific mechanical stimuli (0.07 or 0.4 g, respectively). (E) Cold pain hypersensitivity evaluation of ipsilateral hind paw by acetone test of female sham and LAS model mice. (F) Heat pain hypersensitivity evaluation of ipsilateral hind paw by Hargreaves test of female sham and LAS model mice. n = 5–9 mice/group. **p < 0.01, *p < 0.05 vs. sham group. Student's t-test was used for statistics in (B). Two-way ANOVA followed by Bonferroni's post-hoc test was used for statistics in all other panels.