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. 2023 May 25;14:1191823. doi: 10.3389/fimmu.2023.1191823

Table 1.

Patient’s clinical features.

Case 1 Case 2 Case 3 Case 4 Case 5
Age (years), sex 60, male 33, female 61, male 59. male 55, male
Involved limb Left arm and leg Left leg Right arm Left arm Left arm
FBDS Yes No No Yes Yes
Days from weakness to FBDS onset 20 – – 13 5
Short-term memory deterioration Yes No Yes Yes No
Psychiatric disorder No No Yes Yes No
EEG Normal Normal Normal Normal Normal
Cranial MRI T2-weighted and FLAIR hyper- intensity in the right hippocampus Normal T2-weighted and FLAIR hyper-intensity in the left hippocampus Normal Normal
CSF analysis Normal Normal Normal Normal Normal
Anti-LGI1 positivity and titer Serum 1:100
CSF 1:3.2
Serum 1:30
CSF1:10
Serum 1:30
CSF1:30
Serum 1:30
CSF1:10
Serum 1:100
CSF1:10
Immunotherapy Methylprednisolone 500mg for 5 days, half decrement every 3 days, subsequent oral steroid tapering Methylprednisolone 1000mg for 3 days, half decrement every 3 days, subsequent oral steroid tapering Methylprednisolone 500mg for 5 days, half decrement every 3 days, subsequent oral steroid tapering Methylprednisolone 500mg for 5 days, half decrement every 3 days, subsequent oral steroid tapering Methylprednisolone 500mg for 7 days, half decrement every 3 days, subsequent oral steroid tapering
Outcome (follow-up) Occasional paroxysmal limb weakness and FBDS (3 months). recurrence (20 months), FBDS reduced after methylprednisolone 500mg, weakness and FBDS disappeared (28 months) Paroxysmal limb weakness disappeared (3 months) Paroxysmal limb weakness disappeared (2 months) Short-term memory deterioration (4 months) Occasional paroxysmal limb weakness and FBDS, normal mental status (2 months) Paroxysmal limb weakness and FBDS disappeared, normal mental status (3 months)