Table 1.
Patient’s clinical features.
| Case 1 | Case 2 | Case 3 | Case 4 | Case 5 | |
|---|---|---|---|---|---|
| Age (years), sex | 60, male | 33, female | 61, male | 59. male | 55, male |
| Involved limb | Left arm and leg | Left leg | Right arm | Left arm | Left arm |
| FBDS | Yes | No | No | Yes | Yes |
| Days from weakness to FBDS onset | 20 | – | – | 13 | 5 |
| Short-term memory deterioration | Yes | No | Yes | Yes | No |
| Psychiatric disorder | No | No | Yes | Yes | No |
| EEG | Normal | Normal | Normal | Normal | Normal |
| Cranial MRI | T2-weighted and FLAIR hyper- intensity in the right hippocampus | Normal | T2-weighted and FLAIR hyper-intensity in the left hippocampus | Normal | Normal |
| CSF analysis | Normal | Normal | Normal | Normal | Normal |
| Anti-LGI1 positivity and titer | Serum 1:100 CSF 1:3.2 |
Serum 1:30 CSF1:10 |
Serum 1:30 CSF1:30 |
Serum 1:30 CSF1:10 |
Serum 1:100 CSF1:10 |
| Immunotherapy | Methylprednisolone 500mg for 5 days, half decrement every 3 days, subsequent oral steroid tapering | Methylprednisolone 1000mg for 3 days, half decrement every 3 days, subsequent oral steroid tapering | Methylprednisolone 500mg for 5 days, half decrement every 3 days, subsequent oral steroid tapering | Methylprednisolone 500mg for 5 days, half decrement every 3 days, subsequent oral steroid tapering | Methylprednisolone 500mg for 7 days, half decrement every 3 days, subsequent oral steroid tapering |
| Outcome (follow-up) | Occasional paroxysmal limb weakness and FBDS (3 months). recurrence (20 months), FBDS reduced after methylprednisolone 500mg, weakness and FBDS disappeared (28 months) | Paroxysmal limb weakness disappeared (3 months) | Paroxysmal limb weakness disappeared (2 months) Short-term memory deterioration (4 months) | Occasional paroxysmal limb weakness and FBDS, normal mental status (2 months) | Paroxysmal limb weakness and FBDS disappeared, normal mental status (3 months) |