Figure 1.

Strategies for the correction of Del52 mutation in DMD gene. This figure represents the substitution, insertion, and deletion strategies to restore the dystrophin expression for the Del52 mutation in the DMD gene using the Prime editing technology. (1) Shows the substitution of one or two nucleotides of the splice sites, (2) shows the insertion of A at the end of exon 51 or at the beginning of exon 53, or the insertion of one or many nucleotides between the two nucleotides of the splice sites (3) and (4) shows the deletion of one or many nucleotides at the splice sites.