Figure 2.

Strategies for the correction of Del45-52. This figure represents the Prime editing strategies for the corrections of Del45-52 in the DMD gene to mediate the dystrophin restoration. These includes the substitutions of one or two nucleotides of the splice sites 53 (1), insertion of A at the end of exon 44 or the beginning of exon 53 (2), insertion of one or many nucleotides between the two nucleotides of the splice sites of exon 53 (3), deletion of one or many nucleotides at the splice sites of exon 53 (4).