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. 2023 May 25;14:1180104. doi: 10.3389/fendo.2023.1180104

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Copyright © 2023 Zhang, Fang, Gao, Zeng, Lu, Liu, Chen, Huang and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BAT-exo treatment improved ovarian function in aging mice. (A) The ovaries of the control group were visibly smaller than those of the BAT and BAT-exo groups. (B) The ovarian organ coefficient of the BAT-exo group was higher than that of the control group. (C) HE staining showed that mice in the BAT and BAT-exo groups had more follicles. Scale bar, 1 mm. (D) Numbers of total follicles in each group. (E) Numbers of follicles at various stages in each group. (F) Quantification of AMH in each group. (G) P21 staining showed that BAT and BAT-exo downregulated P21 expression. Scale bar, 200 μm.*p < 0.05, **p < 0.01.