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. 2023 May 25;14:1180104. doi: 10.3389/fendo.2023.1180104

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Copyright © 2023 Zhang, Fang, Gao, Zeng, Lu, Liu, Chen, Huang and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BAT-exos inhibited the decline in mitochondrial function in oocytes. (A) The number of MII-stage oocytes after ovulation induction. (B) The rate of in vitro maturation (IVM). (C) The mitochondrial structure acquired by TEM. Scale bar, 200 nm. (D) BAT-exo and BAT interventions reduced the level of ROS. Scale bar, 20 μm. (E) Quantification of ROS. (F) The mitochondrial membrane potential was higher in the BAT and BAT-exo groups than in the control group. Scale bar, 50 μm. (G) Quantification of mitochondrial membrane potential. (H) BAT-exo treatment increased the ATP levels in oocytes. *p < 0.05, **p < 0.01.