Table 1.

MR estimates for the relationship between genetically instrumented gut microbiota and periodontitis.

Exposure	Method	OR	95% CI	p-value
Enterobacteriales	IVW	1.37	1.07-1.74	0.012
	WM	1.36	1.01-1.85	0.046
	MR-Egger	0.49	0.13-1.81	0.336
Pasteurellales	IVW	1.12	1.01-1.25	0.039
	WM	1.13	0.96-1.32	0.130
	MR-Egger	1.18	0.92 -1.53	0.2163
Enterobacteriaceae	IVW	1.37	1.07-1.74	0.012
	WM	1.36	1.00-1.86	0.051
	MR-Egger	0.49	0.13-1.81	0.336
Pasteurellaceae	IVW	1.12	1.01-1.25	0.039
	WM	1.13	0.97-1.31	0.117
	MR-Egger	1.18	0.92-1.53	0.216
Bacteroidales S24.7 group	IVW	1.16	1.01-1.33	0.042
	WM	1.16	0.97-1.38	0.113
	MR-Egger	1.12	0.64-1.97	0.702
Prevotella 7	IVW	1.14	1.05-1.25	0.002
	WM	1.13	1.01-1.26	0.028
	MR-Egger	1.12	0.67-1.88	0.681
Lachnospiraceae UCG008	IVW	1.19	1.04-1.38	0.014
	WM	1.20	1.02-1.42	0.032
	MR-Egger	1.24	0.53-2.89	0.633
Butyricicoccus	IVW	0.82	0.68-0.98	0.030
	WM	0.83	0.64-1.08	0.161
	MR-Egger	0.85	0.60-1.20	0.384
Alistipes	IVW	1.20	1.01-1.42	0.034
	WM	1.20	0.96-1.50	0.117
	MR-Egger	0.86	0.37-2.00	0.736
Ruminiclostridium 6	IVW	0.86	0.74-0.99	0.038
	WM	0.88	0.72-1.08	0.211
	MR-Egger	0.89	0.60-1.30	0.548
Eisenbergiella	IVW	1.12	1.00-1.25	0.046
	WM	1.04	0.90-1.21	0.580
	MR-Egger	1.52	0.63-3.63	0.372

MR, Mendelian randomization; CI, confidence interval; OR, odds ratio; IVW, inverse variance-weighted; WM, weighted median.