Figure 4.

Persistence of the specific response against SARS-CoV-2. (A–D) Graphs show the frequency of spike-specific S+ MBCs (A) S++ MBCs (B), RBD+ MBCs (C), the concentration of anti-S1 IgG (D) and the neutralizing antibody titers for the wild type and the BA.5 variant (E), after the 3^rd dose, before and 10 days after the 4^th dose in the four groups of CVIDs patients. Medians are shown as bars and the dotted line indicates the cut-off. Non-parametric Wilcoxon matched pair signed-rank test and Mann–Whitney t-test were used to evaluate statistical significance. Two-tailed P value significances are shown as *p<0.05, **p< 0.01, ***p< 0.001.