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. 2023 May 25;14:1194225. doi: 10.3389/fimmu.2023.1194225

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Copyright © 2023 Piano Mortari, Pulvirenti, Marcellini, Terreri, Salinas, Ferrari, Di Napoli, Guadagnolo, Sculco, Albano, Guercio, Di Cecca, Milito, Garzi, Pesce, Bonanni, Sinibaldi, Bordoni, Di Cecilia, Accordini, Castilletti, Agrati, Quintarelli, Zaffina, Locatelli, Carsetti and Quinti

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CD4+ T-cell population in the 4 groups. (A) X-Shift B-cell cluster sets originated from the four concatenated groups and overlaid onto the Opt-SNE map, each cluster is indicated by a color. Naïve T cells were identified in two clusters 2 and 7 and were merged together. (B) Expression of CD45RO, CD40L, IFNγ, and TNFα for population characterization and identification. (C) Merged Opt-SNE plots for each group with relative X-Shift cluster sets overlaid onto the Opt-SNE map. (D) Heat map depicts the cluster sets abundancy (%) in the four groups.