Fig. 4.

Bromocriptine monotherapy inhibits the skeletal growth of chemoresistant PCa cells in male athymic nude mice. (A) Serum PSA levels of mice inoculated with intratibial C4-2B-TaxR cells and treated with vehicle control (n = 6) and bromocriptine (15 mg/kg; n = 6), three times per week, via i.p injection. Two-way ANOVA analysis was used to evaluate the statistical difference in the PSA values between different treatment groups. ***: p < 0.001. (B) Left: average body weights of mice treated with vehicle or bromocriptine; right: percentage of change in the average body weight under different treatments. (C) X-ray radiography of tumor-bearing tibia under different treatments. (D) H&E staining of C4-2B-TaxR tumors and tissue expression of Ki67 in mice under different treatments. Scale bar: 100 µm.