Table 3. The median survival time and multivariable Cox regression for analyzing the overall survival of lung metastases of non-surgery and surgery.
| Cancer system | Cancer site | Non-surgery (months), median (95% CI) | Surgery (months), median (95% CI) | Log Rank | P value | HR (95% CI) | P |
|---|---|---|---|---|---|---|---|
| – | All patients | 4.00 (3.94–4.06) | 19.00 (18.45–19.55) | 8792.07 | <0.001 | 0.49 (0.48–0.51) | <0.001 |
| Oral cavity and pharynx system | Lip | 1.00 (0.37–1.63) | 5.00 | 2.46 | 0.117 | 0.00 (0.00–0.01) | 0.013 |
| Tongue | 7.00 (5.28–8.72) | 11.00 (6.17–1.83) | 7.46 | 0.006 | 0.54 (0.37–0.80) | 0.002 | |
| Salivary gland | 8.00 (5.42–10.56) | 23.00 (16.93–29.07) | 27.19 | <0.001 | 0.38 (0.26–0.56) | <0.001 | |
| Floor of mouth | 5.00 (2.94–7.06) | 20.00 (4.90–35.11) | 8.12 | 0.004 | 0.28 (0.11–0.71) | 0.007 | |
| Gum and other mouth | 5.00 (3.47–6.53) | 8.00 (4.06–11.94) | 3.72 | 0.054 | 0.60 (0.36–1.00) | 0.051 | |
| Larynx | 6.00 (5.07–6.93) | 12.00 (8.86–15.14) | 11.61 | 0.001 | 0.55 (0.39–0.80) | 0.001 | |
| Nasopharynx | 13.00 (8.67–17.33) | 20.00 | 2.60 | 0.107 | 0.64 (0.25–1.64) | 0.411 | |
| Tonsil | 9.00 (7.50–10.51) | 17.00 (1.35–32.65) | 4.03 | 0.045 | 0.64 (0.36–1.13) | 0.122 | |
| Oropharynx | 5.00 (2.99–7.01) | 6.00 (0.00–12.20) | 1.21 | 0.271 | 0.65 (0.30–1.40) | 0.272 | |
| Hypopharynx | 6.00 (4.23–7.77) | 16.00 (3.60–28.40) | 4.59 | 0.032 | 0.50 (0.26–0.96) | 0.037 | |
| Other oral cavity and pharynx | 3.00 (1.24–4.76) | 12.00 (0.00–25.72) | 0.73 | 0.391 | 1.23 (0.35–4.29) | 0.742 | |
| Nose, nasal cavity and middle ear | 7.00 (0.78–13.22) | 14.00 (8.91–19.09) | 2.37 | 0.124 | 0.65 (0.31–1.34) | 0.241 | |
| Subtotal | 7.00 (6.42–7.58) | 16.00 (12.68–19.32) | 74.99 | <0.001 | 0.50 (0.43–0.58) | <0.001 | |
| Digestive system | Esophagus | 4.00 (3.72–4.29) | 10.00 (6.63–13.37) | 14.60 | <0.001 | 0.56 (0.40–0.79) | 0.001 |
| Stomach | 3.00 (2.72–3.28) | 6.00 (4.22–7.78) | 13.36 | <0.001 | 0.62 (0.50–0.77) | <0.001 | |
| Small intestine | 5.00 (3.36–6.64) | 12.00 (7.36–16.64) | 10.02 | 0.002 | 0.74 (0.55–1.01) | 0.059 | |
| Colon cancer | 4.00 (3.66–4.34) | 15.00 (13.94–16.06) | 739.75 | <0.001 | 0.58 (0.55–0.62) | <0.001 | |
| Rectum and rectosigmoid junction | 11.00 (10.27–11.73) | 26.00 (23.04–28.07) | 294.04 | <0.001 | 0.55 (0.50–0.60) | <0.001 | |
| Anus, anal canal and anorectum | 9.00 (6.80–11.20) | 10.00 (5.51–14.49) | 0.17 | 0.68 | 1.01 (0.69–1.48) | 0.970 | |
| Liver and intrahepatic bile duct | 2.00 (1.90–2.11) | 20.00 (11.33–28.67) | 178.43 | <0.001 | 0.29 (0.22–0.37) | <0.001 | |
| Gallbladder cancer | 3.00 (2.46–3.54) | 6.00 (3.67–8.33) | 4.89 | 0.027 | 0.74 (0.53–1.05) | 0.095 | |
| Other biliary | 2.00 (1.65–2.36) | 11.00 (4.56–17.44) | 14.46 | <0.001 | 0.58 (0.35–0.99) | 0.045 | |
| Pancreas | 2.00 (1.89–2.12) | 12.00 (8.45–15.55) | 79.77 | <0.001 | 0.41 (0.33–0.52) | <0.001 | |
| Retroperitoneum | 5.00 (2.52–7.48) | 18.00 (11.09–24.92) | 7.96 | 0.005 | 0.68 (0.44–1.05) | 0.078 | |
| Peritoneum, omentum and mesentery | 7.00 (3.69–10.31) | 29.00 (25.32–32.68) | 26.19 | <0.001 | 0.53 (0.36–0.79) | 0.002 | |
| Other digestive organs | 2.00 (1.77–2.23) | 6.00 (0.16–11.84) | 2.62 | 0.015 | 1.06 (0.50–2.23) | 0.876 | |
| Subtotal | 3.00 (2.92–3.08) | 17.00 (16.16–17.84) | 2653.93 | <0.001 | 0.47 (0.46–0.49) | <0.001 | |
| Respiratory system | Lung and bronchus | 4.00 (3.91–4.09) | 16.00 (14.19–17.81) | 752.60 | <0.001 | 0.42 (0.40–0.45) | <0.001 |
| Pleura | 0.00 | 3.00 | 0.14 | 0.702 | 0.08 | ||
| Trachea, mediastinum and other respiratory organs | 7.00 (4.35–9.66) | 17.00 (8.57–25.43) | 16.66 | <0.001 | 0.42 (0.25–0.71) | 0.001 | |
| Subtotal | 4.00 (3.91–4.09) | 16.00 (14.23–17.77) | 777.86 | <0.001 | 0.42 (0.40–0.45) | <0.001 | |
| Bones and joints system | Bones and joints | 10.00 (8.02–11.98) | 29.00 (23.00–35.00) | 59.78 | <0.001 | 0.62 (0.49–0.79) | <0.001 |
| Soft tissue and skin system | Melanoma of the skin | 5.00 (4.61–5.39) | 11.00 (9.60–12.40) | 72.16 | <0.001 | 0.70 (0.63–0.78) | <0.001 |
| Soft tissue including heart | 5.00 (4.35–5.65) | 16.00 (13.73–18.27) | 181.85 | <0.001 | 0.50 (0.44–0.57) | <0.001 | |
| Other non-epithlia skin | 6.00 (2.75–9.25) | 9.00 (6.31–11.69) | 0.98 | 0.323 | 0.62 (0.35–1.09) | 0.097 | |
| Mesothelioma | 4.00 (3.09–4.91) | 9.00 (5.99–12.01) | 9.21 | 0.002 | 0.72 (0.52–1.00) | 0.050 | |
| Eye and orbit | 4.00 (1.70–6.30) | 37.00 (4.26–69.74) | 6.32 | 0.012 | 0.80 (0.15–4.28) | 0.791 | |
| Kaposi sarcoma | 0.28 | 0.597 | 0.00 | 0.599 | |||
| Subtotal | 5.00 (4.68–5.32) | 13.00 (11.85–14.15) | 269.51 | <0.001 | 0.59 (0.54–0.63) | <0.001 | |
| Female genital system | Cervix uteri | 6.00 (5.34–6.66) | 12.00 (10.09–13.91) | 16.94 | <0.001 | 0.63 (0.48–0.82) | 0.001 |
| Breast cancer | 15.00 (14.11–15.89) | 29.00 (26.71–31.29) | 216.38 | <0.001 | 0.71 (0.66–0.76) | <0.001 | |
| Corpus and uterus, NOS | 3.00 (2.61–3.39) | 14.00 (12.60–15.40) | 341.18 | <0.001 | 0.50 (0.45–0.56) | <0.001 | |
| Ovary | 3.00 (2.53–3.47) | 30.00 (27.68–32.32) | 607.92 | <0.001 | 0.37 (0.32–0.43) | <0.001 | |
| Vagina | 5.00 (2.92–7.08) | 18.00 (2.81–33.19) | 2.15 | 0.143 | 0.68 (0.32–1.44) | 0.316 | |
| Vulva | 3.00 (1.90–4.11) | 6.00 (2.73–9.27) | 4.80 | 0.029 | 0.48 (0.30–0.75) | 0.001 | |
| Other female genital organs | 16.00 (7.05–24.95) | 47.00 (32.50–61.50) | 14.17 | <0.001 | 1.09 (0.69–1.74) | 0.708 | |
| Subtotal | 9.00 (8.53–9.47) | 24.00 (22.69–25.31) | 675.06 | <0.001 | 0.69 (0.66–0.73) | <0.001 | |
| Male genital system | Penis | 2.00 (0.21–3.79) | 7.00 (5.24–8.76) | 2.05 | 0.152 | 0.51 (0.20–1.34) | 0.170 |
| Testis | 8.00 (4.25–11.75) | 0.00 | 181.87 | <0.001 | 0.33 (0.24–0.47) | <0.001 | |
| Subtotal | 7.00 (3.31–10.69) | 204.66 | <0.001 | 0.37 (0.27–0.51) | <0.001 | ||
| Urinary system | Prostate | 12.00 (10.99–13.01) | 18.00 (14.19–21.81) | 11.36 | 0.001 | 0.84 (0.70–1.00) | 0.054 |
| Urinary | 2.00 (1.63–2.37) | 5.00 (4.46–5.54) | 54.33 | <0.001 | 0.83 (0.74–0.93) | 0.001 | |
| Kidney and renal pelvis | 4.00 (3.82–4.18) | 19.00 (17.47–20.54) | 1597.74 | <0.001 | 0.40 (0.37–0.43) | <0.001 | |
| Ureter | 4.00 (2.63–5.37) | 7.00 (5.18–8.82) | 4.27 | 0.039 | 0.90 (0.47–1.70) | 0.740 | |
| Other urinary organs | 2.00 (0.95–3.05) | 9.00 (7.13–10.88) | 2.69 | 0.101 | 0.76 (0.44–1.31) | 0.318 | |
| Subtotal | 5.00 (4.77–5.23) | 13.00 (12.30–13.70) | 837.30 | <0.001 | 0.69 (0.66–0.73) | <0.001 | |
| Nervous system | Cranial nerves other nervous system | 1.00 | 46.00 (0.00–106.01) | 1.10 | 0.294 | 0.00 (0.00–0.001) | 0.474 |
| Brain | 6.00 (0.00–15.79) | 7.00 (2.85–11.15) | 0.08 | 0.766 | 0.54 (0.20–1.48) | 0.230 | |
| Subtotal | 5.00 (0.00–11.09) | 10.00 (0.00–20.76) | 2.11 | 0.146 | 0.33 (0.15–0.76) | 0.009 | |
| Endocrine system | Other endocrine including thymus | 9.00 (6.27–11.74) | 48.00 (40.69–55.31) | 59.12 | <0.001 | 0.31 (0.23–0.42) | <0.001 |
| Thyroid | 2.00 (1.49–2.51) | 59.00 (41.39–70.61) | 412.80 | <0.001 | 0.28 (0.23–0.33) | <0.001 | |
| Subtotal | 4.00 (3.27–4.73) | 53.00 (43.22–63.78) | 409.71 | <0.001 | 0.26 (0.22–0.30) | <0.001 | |
| Lymphatic system | Non-Hodgkin lymphoma | 12.00 (8.52–15.48) | 32.00 (23.88–40.13) | 5.97 | 0.015 | 0.55 (0.35–0.87) | 0.010 |
| Hodgkin lymphoma | 1.43 | 0.232 | 1.72 (0.00–2.86) | 0.964 | |||
| Subtotal | 15.00 (11.50–18.50) | 32.00 (11.82–52.19) | 6.64 | 0.01 | 0.52 (0.33–0.82) | 0.004 | |
| Blood system | Leukemia | 6.00 (2.83–9.17) | 42.00 (20.61–63.39) | 15.75 | <0.001 | 0.31 (0.15–0.66) | 0.002 |
| Myeloma | 6.00 (1.61–10.39) | 7.00 (0.76–13.24) | 0.41 | 0.522 | 0.46 (0.12–1.78) | 0.262 | |
| Subtotal | 6.00 (3.43–8.57) | 27.00 (14.08–39.92) | 15.58 | <0.001 | 0.42 (0.23–0.77) | 0.005 | |
| Other system | Miscellaneous | 6.00 (1.89–10.11) | 23.00 (1.12–44.88) | 4.20 | 0.041 | 0.49 (0.20–1.17) | 0.107 |
Adjustment factors: adjusted for Ages at diagnosis, Sex, Marriage, Insurance, Race, Income, Grade, T stage, N stage, Radiation, Chemotherapy, Bone metastases, Brain metastases, Liver metastases. CI, confidence interval; HR, hazard ratio; NOS, not otherwise specified.