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. 2023 Jun 8;13(25):17166–17178. doi: 10.1039/d3ra01460f

Design and results of Box–Behnken.

Run A B C Conversion/% Selectivity/% BHET yield/% Residual (%)
Actual Predicted
1 0 0 0 100 85.60 85.60 85.20 0.40
2 0 0 0 100 85.60 85.60 85.20 0.40
3 0 0 0 100 85.60 85.60 85.20 0.40
4 −1 −1 0 100 73.00 73.00 75.45 −2.45
5 −1 0 1 100 89.40 89.40 87.05 2.35
6 1 1 0 100 85.40 85.40 82.95 2.45
7 0 0 0 100 85.60 85.60 85.20 0.40
8 −1 0 −1 100 75.40 75.40 72.95 2.45
9 −1 1 0 100 86.00 86.00 88.35 −2.35
10 0 −1 −1 100 69.40 69.40 69.40 0.00
11 0 −1 1 100 79.10 79.10 79.00 0.10
12 1 0 −1 100 77.20 77.20 79.55 −2.35
13 0 0 0 100 83.60 83.60 85.20 −1.60
14 1 −1 0 100 74.60 74.60 72.25 2.35
15 0 1 1 100 84.40 84.40 84.40 0.00
16 0 1 −1 100 87.50 87.50 87.60 −0.10
17 1 0 1 100 69.40 69.40 71.85 −2.45