Table 4.

Prognostication of Future HF Events and Death by AUC Analysis

	C-Statistic Primary Model (95% CI)	C-Statistic Comparison Model (95% CI)	Difference (95% CI)	P Value
HF events
Model A vs model B1	0.717 (0.698-0.737)	0.758 (0.740-0.776)	0.040 (0.029-0.052)	<0.001
Model A vs model B2	0.717 (0.698-0.737)	0.753 (0.735-0.770)	0.035 (0.025-0.045)	<0.001
Model A vs model B3	0.717 (0.698-0.737)	0.778 (0.762-0.795)	0.061 (0.048-0.074)	<0.001
Model B1 vs model B3	0.758 (0.740-0.776)	0.778 (0.762-0.795)	0.020 (0.014-0.027)	<0.001
Death
Model A vs model B1	0.683 (0.666-0.699)	0.693 (0.677-0.709)	0.010 (0.004-0.016)	0.001
Model A vs model B2	0.683 (0.666-0.699)	0.701 (0.685-0.717)	0.018 (0.011-0.025)	<0.001
Model A vs model B3	0.683 (0.666-0.699)	0.706 (0.690-0.722)	0.023 (0.015-0.031)	<0.001
Model B1 vs model B3	0.693 (0.677-0.709)	0.706 (0.690-0.722)	0.013 (0.008-0.019)	<0.001

Model A = risk factors model; model B1 = risk factors + cardiac structural/functional abnormality on echo; model B2 = risk factors + elevated biomarkers; model B3 = risk factors + structural/functional abnormality on echo + elevated biomarkers.

AUC = area under the curve; other abbreviation as in Table 1.