Table 1.

Summary of the AOP.

Sequence	Type	Event ID	Title	Short name
1	MIE	1115	Excessive generation of reactive oxygen species	Excessive generation of ROS
2	MIE	151	Release of inflammatory cytokines	Release of inflammatory cytokines
3	MIE	559	Activation of nicotinic acetylcholine receptor	Activation of nicotinic acetylcholine receptor
4	KE	1392	Oxidative stress	Oxidative stress
5	KE	1198	Macrophage activation	Macrophage activation
6	KE	1913	Endothelial cell dysfunction	Endothelial cell dysfunction
7	KE	1925	Vascular smooth muscle cell activation	Vascular smooth muscle cell activation
8	KE	1500	Fibroblast proliferation and myofibroblast differentiation	Cellular proliferation and differentiation
9	KE	1918	Myocardial apoptosis	Myocardial apoptosis
10	KE	2004	Secretion of catecholamine	Secretion of catecholamine
11	KE	1443	Atherosclerosis	Atherosclerosis
12	KE	2003	Vascular remodeling	Vascular remodeling
13	KE	2000	Vascular calcification	Vascular calcification
14	KE	1924	Cardiac fibrosis	Cardiac fibrosis
15	KE	2002	Ventricular remodeling	Ventricular remodeling
16	KE	2001	Cardiac hypertrophy	Cardiac hypertrophy
18	AO	1929	Increased incidence of cardiovascular morbidity and mortality in the general population	Increased incidence of cardiovascular morbidity and mortality

Molecular Initiating Event (MIE), Key Event (KE), Adverse outcome (AO).