Table 1.
Per cancer type and time period, the number of newly diagnosed patients with de novo metastatic disease and the mean age
| Cancera | 1989-1993, No. | Mean age (95% CI), y | Male, No. (%) | 2014-2018, No. | Mean age (95% CI), y | Male, No. (%) | Increase or decrease |
|---|---|---|---|---|---|---|---|
| Prostate | 5477 | 74 (73 to 74) | 5477 (100) | 8491 | 73 (73 to 73) | 8491 (100) | ↓ |
| Testicular | 210 | 32 (30 to 33) | 210 (100) | 293 | 35 (34 to 36) | 293 (100) | ↑ |
| Thyroid | 182 | 67 (65 to 69) | 64 (35) | 259 | 67 (66 to 69) | 116 (45) | ≠ |
| Breast | 2808 | 64 (63 to 64) | 12 (0) | 3826 | 63 (62 to 63) | 42 (1) | ↓ |
| NET | 304 | 64 (63 to 65) | 158 (52) | 840 | 64 (63 to 65) | 466 (55) | ≠ |
| Vulva/vagina | 27 | 70 (65 to 76) | 0 (0) | 85 | 71 (69 to 74) | 0 (0) | ↑ |
| Melanoma | 440 | 57 (55 to 58) | 249 (57) | 1041 | 63 (62 to 64) | 639 (61) | ↑ |
| Ovarian | 1060 | 66 (65 to 67) | 0 (0) | 1517 | 68 (68 to 69) | 0 (0) | ↑ |
| Corpus uteri | 248 | 69 (68 to 70) | 0 (0) | 672 | 70 (69 to 71) | 0 (0) | |
| GIST | 50 | 59 (56 to 63) | 21 (42) | 160 | 66 (64 to 68) | 101 (63) | ↑ |
| Rectum | 1956 | 67 (67 to 68) | 1159 (59) | 3644 | 66 (66 to 66) | 2254 (62) | ↓ |
| Cervix uteri | 144 | 59 (57 to 62) | 0 (0) | 373 | 58 (57 to 60) | 0 (0) | ↓ |
| Sarcoma | 390 | 57 (55 to 59) | 214 (55) | 545 | 60 (59 to 62) | 329 (60) | ↑ |
| Colon | 4753 | 68 (68 to 69) | 2259 (48) | 9332 | 68 (68 to 68) | 4961 (53) | ≠ |
| Kidney | 1489 | 65 (64 to 65) | 918 (62) | 2205 | 67 (67 to 68) | 1467 (67) | ↑ |
| HNSCC | 97 | 62 (60 to 64) | 77 (79) | 238 | 66 (64 to 67) | 178 (75) | ↑ |
| Bladder | 549 | 69 (68 to 70) | 384 (70) | 1768 | 70 (70 to 71) | 1164 (66) | ↑ |
| Other solid cancers | 811 | 65 (64 to 66) | 364 (45) | 1187 | 65 (64 to 65) | 586 (49) | ≠ |
| Cancers with an unknown primary site | 11 659 | 69 (69 to 69) | 6406 (55) | 5280 | 73 (72 to 73) | 2661 (50) | ↑ |
| SCLC | 3575 | 66 (65 to 66) | 2871 (80) | 4873 | 67 (67 to 68) | 2564 (53) | ↑ |
| Esophagus/cardia | 1646 | 65 (64 to 65) | 1229 (75) | 4387 | 67 (67 to 67) | 3464 (79) | ↑ |
| Stomach | 2720 | 69 (68 to 69) | 1697 (62) | 2148 | 69 (68 to 69) | 1329 (62) | ≠ |
| NSCLC | 7510 | 65 (65 to 65) | 6055 (81) | 19 868 | 67 (67 to 67) | 11 262 (57) | ↑ |
| Lung other | 1045 | 70 (70 to 71) | 874 (84) | 2890 | 76 (75 to 76) | 1706 (59) | ↑ |
| Bile ducts | 289 | 69 (67 to 70) | 133 (46) | 1347 | 67 (66 to 67) | 665 (49) | ↓ |
| Hepatocellular | 114 | 62 (59 to 65) | 69 (61) | 508 | 68 (67 to 69) | 395 (78) | ↑ |
| Gallbladder | 339 | 71 (70 to 72) | 73 (22) | 383 | 70 (69 to 71) | 111 (29) | ↓ |
| Pancreas | 2371 | 67 (66 to 67) | 1288 (54) | 6223 | 69 (69 to 69) | 3275 (53) | ↑ |
| Total | 52 263 | 67 (67 to 67) | 20 002 (62) | 84 383 | 68 (68 to 68) | 48 519 (57) | ↑ |
a
See Supplementary Table 2 (available online) for a detailed description of the cancer types; ↑ = increase; ↓ = decrease; ≠ = remained the same. CI = confidence interval; GIST = gastrointestinal stromal tumors; HNSCC = head and neck squamous cell carcinoma; NET = neuroendocrine tumor; NSCLC = non-small cell lung cancer; SCLC = small cell lung cancer.