Table 2.
Newly identified genetic variants from the cross-cancer GWAS meta-analysis (P < 1.25 × 10−8)
| Region | Variant ID | Chr | Positiona | Function | MAF (gnomAD EUR) | Effect allele | Other allele | P b |
|---|---|---|---|---|---|---|---|---|
| 2p25.3 | rs66906321 | 2 | 630070 | Intergenic | 0.17 | T | C | 1.12 x 10−8 |
| 2q24.2 | rs146071273 | 2 | 161628983 | Intergenic | 0.10 | A | G | 8.23 x 10−9 |
| 2q32.1 | rs62172372 | 2 | 188242369 | Intronic (CALCRL) | 0.22 | A | G | 1.21 x 10−8 |
| 2q37.1 | rs34755199 | 2 | 233516534 | Intronic (EFHD1) | 0.48 | A | AAAAC | 9.49 x 10−9 |
| 6p24.3 | rs9379084 | 6 | 7231843 | Missense (RREB1) | 0.12 | A | G | 9.10 x 10−9 |
| 15q15.3 | rs533143 | 15 | 44188854 | Intron (FRMD5) | 0.27 | T | C | 3.84 x 10−10 |
| 18q21.31 | rs8097764 | 18 | 55317896 | Intronic (ATP8B1) | 0.12 | A | G | 1.03 x 10−8 |
a
hg19. Chr = chromosome; MAF = minor allele frequency in non-Finnish European ancestry populations based on the Genome Aggregation Database (gnomAD EUR).
b
P values are based on the meta-analysis approach showing the lowest P value.