Table 3.
Newly identified genes from cross-cancer TWAS analyses using either noncancerous (GTEx) tissue or tumor tissue (TCGA)a
| Panel | Gene | Chr | Locus | Tissue | P |
|---|---|---|---|---|---|
| GTEx | ALKAL2 | 2 | 2p25.3 | Cross-tissue | 4.41 x 10−8 |
| GTEx | CALCRL | 2 | 2q32.1 | Aorta artery | 1.12 x 10−7 |
| GTEx | CALCRL | 2 | 2q32.1 | Tibial nerve | 8.33 x 10−8 |
| GTEx | IKZF2 | 2 | 2q34 | Thyroid | 6.28 x 10−8 |
| GTEx | IGFBP3 | 7 | 7p12.3 | Thyroid | 1.23 x 10−7 |
| GTEx | MEPCE | 7 | 7q22.1 | Fibroblasts | 6.79 x 10−8 |
| GTEx | NEK6 | 9 | 9q33.3 | Cross-tissue | 9.69 x 10−8 |
| GTEx | LGR4 | 11 | 11p14.1 | Cross-tissue | 1.00 x 10−7 |
| GTEx | IGBP1P1 | 14 | 14q13.2 | Pancreas | 7.72 x 10−8 |
| TCGA | C5 | 9 | 9q33.2 | Cross-tissue | 4.33 x 10−7 |
| TCGA | C5 | 9 | 9q33.2 | Prostate | 2.16 x 10−7 |
| TCGA | LOC284900 | 22 | 22q11.21-q12.1 | Renal papillary cell | 1.75 x 10−7 |
| TCGA | LOC284900 | 22 | 22q11.21-q12.1 | Stomach | 2.46 x 10−7 |
a
Genes that were statistically significant for multiple tissues are listed more than once. Chr = chromosome; GTEx = Genotype-Tissue Expression project; TCGA = The Cancer Genome Atlas; TWAS = transcriptome-wide association studies.