Table 1. IC50 and SI Data for Compounds 2, 3a–j, and Cisplatin.
| compound | IC50 (μM) |
SIa | |
|---|---|---|---|
| A549 cell line | L929 cell line | ||
| 2 | >500 | >500 | |
| 3a | 91.35 ± 21.89 | >500 | >5.47 |
| 3b | 410.15 ± 220.38 | >500 | |
| 3c | >500 | >500 | |
| 3d | >500 | >500 | |
| 3e | 176.23 ± 56.50 | >500 | >2.84 |
| 3f | 250.61 ± 45.87 | >500 | |
| 3g | 46.60 ± 6.15 | 276.67 ± 28.87 | 5.94 |
| 3h | >500 | >500 | |
| 3i | 83.59 ± 7.30 | >500 | >5.98 |
| 3j | >500 | >500 | |
| Cisplatin | 23.89 ± 2.71 | ||
SI = IC50 for L929 cells/IC50 for A549 cells.