Table 2. Results of the In Vitro Pim-1 Inhibition Assay and Docking Interaction Energy.

comp. no	IC50 (μM),a Pim-1 inhibition	docking interaction energy (kcal/mol), PDB ID: 2OBJ	docking interaction energy (kcal/mol), PDB ID: 2O64
quercetagetin	0.56 ± 0.03	NTb	–14.53
compound A	0.93 ± 0.05	–10.67	NTb
3a	0.90 ± 0.04	–11.68	–11.60
3b	0.85 ± 0.04	–11.57	–11.97
3c	0.79 ± 0.04	–11.16	–11.80
3d	0.72 ± 0.03	–11.37	–11.03
3e	2.31 ± 0.11	–11.48	–11.08
4a	1.24 ± 0.06	–11.71	–11.20
4b	0.63 ± 0.03	–11.64	–11.81
4c	0.61 ± 0.03	–12.01	–12.23
4d	0.46 ± 0.02	–12.04	–12.43
4e	1.42 ± 0.07	–11.58	–11.25

^aIC₅₀ (μM): expressed as mean ± S.D.

^bNT: not tested.