Table 2.

Association of air pollution (pre-diagnosis exposure) with the severity of SSc-associated ILD at diagnosis (extensive ILD)

	OR	p value
NO2	0.95 (0.91–1.00)	0.08
O3	1.12 (1.05–1.21)	0.002
PM10	0.91 (0.75–1.11)	0.36
PM2.5	0.87 (0.64–1.20)	0.39

Logistic regression models adjusted for birth in Europe, tobacco smoking, anti-topoisomerase I antibodies positivity, usual interstitial pneumonia pattern, time between first non-Raynaud symptom and ILD diagnosis, and year of ILD diagnosis

ILD: interstitial lung disease; NO₂: nitrogen dioxide; O₃: ozone; PM₁₀ and PM_2.5: particles with a 50% cutoff aerodynamic diameter of 10 µm and 2.5 µm, respectively