Table 3.
Association of pre-diagnosis exposure to ozone pollution with the severity of SSc-associated ILD at diagnosis (extensive ILD): two-pollutant model
| OR | p value | |
|---|---|---|
| O3 | ||
| + NO2 | 1.24 (1.08–1.51) | 0.007 |
| + PM10 | 1.16 (1.06–1.30) | 0.002 |
| + PM2.5 | 1.19 (1.06–1.34) | 0.003 |
Logistic regression model adjusted for birth in Europe, tobacco smoking, anti-topoisomerase I antibodies positivity, usual interstitial pneumonia pattern, time between first non-Raynaud symptom and ILD diagnosis and year of ILD diagnosis
ILD: interstitial lung disease; NO2: nitrogen dioxide; O3: ozone; PM10 and PM2.5: particles with a 50% cutoff aerodynamic diameter of 10 µm and 2.5 µm, respectively