Table 4.

DFI Results of Infertility Cohort. Shows the DNA Fragmentation Index (DFI) results of cohort of 209 human male infertility subjects as compared to multiple different lifestyle variables. Logistics regression models were used to test the relationship between categorical variables and DFI, and linear regression models were used to find the relationship between continuous variables and DFI

Outcome: DFI High
Variable	Value	Estimate	Standard error	t-value	p-value
Age	age in years	0.19	0.06	2.94	*0.0037
Exposure to heat (yes/no)	yes	0.42	0.91	0.46	0.6493
Outside/inside job	inside	2.70	3.55	0.76	0.4482
Outside/inside job	outside	1.18	3.62	0.33	0.7442
Exposure to radiation/chemicals (yes/no)	yes	0.02	0.94	0.02	0.9868
Tobacco use (yes/no)	yes	0.64	0.86	0.75	0.4559
Level of alcohol use	heavy	-0.26	1.22	-0.21	0.8308
Level of alcohol use	moderate	1.09	0.93	1.17	0.2428
Level of alcohol use	rare	-0.29	0.91	-0.32	0.7510
Outcome: DFI Moderate
Variable	Value	Estimate	Standard error	t-value	p-value
Age	age in years	0.15	0.07	2.17	*0.0309
Exposure to heat (yes/no)	yes	-0.09	0.98	-0.09	0.9252
Outside/inside job	inside	1.68	3.79	0.44	0.6577
Outside/inside job	outside	0.09	3.86	0.02	0.9823
Exposure to radiation/chemical (yes/no)	yes	0.16	1.01	0.16	0.8702
Tobacco use (yes/no)	yes	0.54	0.92	0.59	0.5577
Level of alcohol use	heavy	-1.22	2.65	-0.46	0.6460
Level of alcohol use	moderate	-1.31	1.25	-1.05	0.2962
Level of alcohol use	rare	-1.49	0.98	-1.51	0.1321
Outcome: Total DFI
Variable	Value	Estimate	Standard error	t-value	p-value
Age	age in years	0.34	0.12	2.80	*0.0056
Exposure to heat (yes/no)	yes	0.35	1.72	0.20	0.8394
Outside/inside job	inside	4.37	6.67	0.66	0.5130
Outside/inside job	outside	1.25	6.81	0.18	0.8544
Exposure to radiation/chemicals (yes/no)	yes	0.19	1.77	0.11	0.9139
Tobacco use (yes/no)	yes	1.19	1.61	0.74	0.4613
Level of alcohol use	heavy	-0.77	2.28	-0.34	0.7370
Level of alcohol use	moderate	0.02	1.75	0.01	0.9896

DFI DNA Fragmentation Index

^*Denotes significance