Table 2.
Anti-TIGIT antibody drugs in clinical development
| Drug | Mechanism of action | Sponsor |
|---|---|---|
| AZD2936 | A bispecific antibody that can target both PD-1 and TIGIT simultaneously | AstraZeneca |
| HLX301 | A bispecific antibody that can target both PD-1 and TIGIT simultaneously | Henlius |
| HB0036 | A bispecific antibody that can target both PD-1 and TIGIT simultaneously | Huaota |
| IBI321 | A bispecific antibody that can target both PD-1 and TIGIT simultaneously | Innovent Biologics |
| MK-7684 A | A fixed-dose combination formulation composed of Vibostolimab and Pembrolizumab | Merck |
| Domvanalimab | A Fc-silent humanized IgG1 monoclonal antibody directed against TIGIT | Arcus Biosciences |
| BMS-986,207 | A Fc-silent humanized IgG1 monoclonal antibody directed against TIGIT | Bristol Myers Squibb |
| BAT6021 | An investigational humanized IgG1 monoclonal antibody directed against TIGIT | Bio-thera |
| PM1021 | An investigational humanized IgG1 monoclonal antibody directed against TIGIT | Biotheus |
| M6223 | An investigational humanized IgG1 monoclonal antibody directed against TIGIT | EMD Serono |
| EOS-448 | An investigational humanized IgG1 monoclonal antibody directed against TIGIT | iTeos |
| Vibostolimab | An investigational humanized IgG1 monoclonal antibody directed against TIGIT | Merck |
| Etigilimab | An investigational humanized IgG1 monoclonal antibody directed against TIGIT | Mereo |
| Tiragolumab | An investigational humanized IgG1 monoclonal antibody directed against TIGIT | Roche |
| Ociperlimab | An investigational humanized IgG1 monoclonal antibody directed against TIGIT | BeiGene |
| ASP8374 | An investigational humanized IgG4 monoclonal antibody directed against TIGIT | Astellas |
| COM902 | An investigational humanized IgG4 monoclonal antibody directed against TIGIT | Compugen |
| IBI939 | An investigational humanized IgG4κ monoclonal antibody directed against TIGIT | Innovent Biologics |
| JS006 | An investigational humanized IgG4κ monoclonal antibody directed against TIGIT | Junshi |
| SEA-TGT | A nonfucosylated antibody that employs sugar engineered antibody against TIGIT | Seagen Inc |
| AB308 | An investigational humanized IgG1 monoclonal antibody directed against TIGIT | Arcus Biosciences |