Table 1.
List of DNT NAMs endpoints measured in multiple-concentration (mc) or single-concentration (sc) screening in the MEA NFA or HCI assay technologies.
| Endpoint | mc | sc | Activity Type | Technology | Cell type | |
|---|---|---|---|---|---|---|
| HCI | ||||||
| 1 | CCTE_Mundy_HCI_CDI_NOG_BPCount_loss | x | x | NOG | HCI | Human |
| 2 | CCTE_Mundy_HCI_CDI_NOG_NeuriteCount_loss | x | x | NOG | HCI | Human |
| 3 | CCTE_Mundy_HCI_CDI_NOG_NeuriteLength_loss | x | x | NOG | HCI | Human |
| 4 | CCTE_Mundy_HCI_CDI_NOG_NeuronCount_loss | x | x | Cytotoxicity (NOG) | HCI | Human |
| 5 | CCTE_Mundy_HCI_hNP1_Casp3_7_gain | x | x | Apoptosis | HCI | Human |
| 6 | CCTE_Mundy_HCI_hNP1_CellTiter_loss | x | x | Cytotoxicity (Apop) | HCI | Human |
| 7 | CCTE_Mundy_HCI_hNP1_Pro_ObjectCount_loss | x | x | Cytotoxicity (Prolif) | HCI | Human |
| 8 | CCTE_Mundy_HCI_hNP1_Pro_ResponderAvgInten_loss | x | x | Proliferation | HCI | Human |
| MEA NFA | ||||||
| 1 | CCTE_Shafer_MEA_dev_active_electrodes_number_dn | x | General activity | MEA NFA | Rat | |
| 2 | CCTE_Shafer_MEA_dev_burst_rate_dn | x | General activity | MEA NFA | Rat | |
| 3 | CCTE_Shafer_MEA_dev_bursting_electrodes_number_dn | x | x | General activity | MEA NFA | Rat |
| 4 | CCTE_Shafer_MEA_dev_firing_rate_mean_dn | x | General activity | MEA NFA | Rat | |
| 5 | CCTE_Shafer_MEA_dev_per_burst_spike_percent_dn | x | General activity | MEA NFA | Rat | |
| 6 | CCTE_Shafer_MEA_dev_burst_duration_mean_dn | x | Bursting | MEA NFA | Rat | |
| 7 | CCTE_Shafer_MEA_dev_per_burst_interspike_interval_dn | x | Bursting | MEA NFA | Rat | |
| 8 | CCTE_Shafer_MEA_dev_correlation_coefficient_mean_dn | x | Network Connectivity | MEA NFA | Rat | |
| 9 | CCTE_Shafer_MEA_dev_mutual_information_norm_dn | x | x | Network Connectivity | MEA NFA | Rat |
| 10 | CCTE_Shafer_MEA_dev_network_spike_duration_std_dn | x | Network Connectivity | MEA NFA | Rat | |
| 11 | CCTE_Shafer_MEA_dev_network_spike_number_dn | x | Network Connectivity | MEA NFA | Rat | |
| 12 | CCTE_Shafer_MEA_dev_network_spike_peak_dn | x | x | Network Connectivity | MEA NFA | Rat |
| 13 | CCTE_Shafer_MEA_dev_per_network_spike_spike_number_mean_dn | x | Network Connectivity | MEA NFA | Rat | |
| 14 | CCTE_Shafer_MEA_dev_per_network_spike_spike_percent_dn | x | Network Connectivity | MEA NFA | Rat | |
| 15 | CCTE_Shafer_MEA_dev_spike_duration_mean_dn | x | Network Connectivity | MEA NFA | Rat | |
| 16 | CCTE_Shafer_MEA_dev_inter_network_spike_interval_mean_dn | x | x | Oscillatory | MEA NFA | Rat |
| 17 | CCTE_Shafer_MEA_dev_interburst_interval_mean_dn | x | Oscillatory | MEA NFA | Rat | |
| 18 | CCTE_Shafer_MEA_dev_LDH_dn | x | x | Cytotoxicity | MEA NFA | Rat |
| 19 | CCTE_Shafer_MEA_dev_AB_dn | x | x | Cytotoxicity | MEA NFA | Rat |