Table 3.
Summary of literature on the antioxidant effects of phlorotannins in various cell lines, tissues, and animal models.
| Oxidative stress stimulant | Substance | Model | Reference |
|---|---|---|---|
| H2O2 | Dieckol | Human endothelial progenitor cells (EPCs) | Lee et al. (2013) |
| Dieckol, EEC | SH-SY5Y human neuroblastoma cell line | Nho et al. (2020) | |
| Dieckol, EEC | PC12 rat pheochromocytoma cell line | Nho et al. (2020) and Shin et al. (2021) | |
| Eckol | Chang liver HeLa/human cervical carcinoma cell line | Kim et al. (2014) | |
| Eckol | HepG2 human liver cancer cell line | Jun et al. (2014) | |
| Eckol, dieckol, PFF-A | MRC-5 human fetal lung fibroblast, RAW264.7 mouse macrophage, HL-60 human promyeloblast cell lines | Li et al. (2009) | |
| AAPH | Eckol, dieckol | Zebrafish embryos | Kang et al. (2013) |
| High glucose | Dieckol | Liver and muscle tissue from C57BL/KsJ-db/db mice (model of type 2 diabetes) | Kang et al. (2013) |
| Dieckol | INS-1 rat pancreatic β-cell insulinoma cell line | Lee et al. (2012) | |
| High-fat diet | EEC | Kidney tissue from C57BL/6 mouse | Eo et al. (2017) |
| EEC | Liver tissue from C57BL/6 mouse | Eo et al. (2015) |
Phlorotannins reduce intracellular ROS levels and increase cell viability after the induction of oxidative stress by H2O2, AAPH, and a high-glucose and high-fat diet. PFF-A, phlorofucofuroeckol A; EEC, ethanol extract of Ecklonia cava; AAPH, 2,2′-azobis(2-amidinopropane) dihydrochloride.