TABLE 3.

Meta-regression Analysis for the Incidence of HO

	Meta-regression coefficient	95% CI	P
Overall HO
Year of publication	−0.06	−0.19 to 0.07	0.301
Age	0.02	−0.02 to 0.06	0.218
Male sex	−0.19	−2.32 to 1.95	0.845
Design (retrospective vs. prospective)	−0.07	−0.42 to 0.27	0.645
Prosthesis type
Prestige LP vs. others	−0.13	−0.54 to 0.27	0.470
Prodisc-C vs. others	0.27	−0.07 to 0.61	0.106
Bryan vs. others	−0.14	−0.52 to 0.24	0.431
Funding source	0.137	−0.29 to 0.56	0.487
CDR at C5/6	−0.78	−2.33 to 0.77	0.264
ROM-pre	0.017	−0.14 to 0.18	0.788
ROM 10-year	−0.05	−0.39 to 0.29	0.706
ASD	−0.34	−2.03 to 1.34	0.634
Severe HO
Year of publication	−0.27	−0.47 to −0.06	0.015 *
Age	0.01	−0.10 to 0.11	0.906
Male sex	−0.38	−4.89 to 4.13	0.853
Design (retrospective vs. prospective)	−0.24	−0.92 to 0.45	0.460
Prosthesis type
Prestige LP vs. others	−0.03	−0.89 to 0.82	0.930
Prodisc-C vs. others	0.37	−0.46 to 1.17	0.347
Bryan vs. others	−0.33	−1.09 to 0.42	0.346
Mobi-C vs. others	0.15	−1.17 to 1.46	0.805
Funding source	0.10	−0.70 to 0.90	0.787
CDR at C5/6	−0.58	−4.10 to 2.93	0.698
ROM-pre	−0.11	−0.60 to 0.37	0.567
ROM 10 yr	−0.31	−0.70 to 0.07	0.091
ASD	−0.80	−3.43 to 1.82	0.492

^* P-value<0.05.

ASD indicates adjacent segment degeneration; CDR, cervical disk replacement; HO, heterotopic ossification; ROM, range of motion.