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. Author manuscript; available in PMC: 2024 Sep 1.
Published in final edited form as: Sens Actuators B Chem. 2023 May 18;390:133994. doi: 10.1016/j.snb.2023.133994

Figure 3.

Figure 3.

Relationship between the PGM readout and the serially diluted AFP biomarker in a 5% human serum solution. (A) Glucose concentration was measured by a PGM after a 30-min (green) or 60-min (blue) glucose-producing reaction. The time for AFP incubation and the CRISPR-Cas12a cleavage reaction was 15 min and 60 min, respectively. n.d. indicates “not detected.” Error bars represent ± standard deviation (s.d.) of three independent experiments. Red dashed line indicates the limit of detection of glucose concentration measured by the PGM (20 mg/dL). (B) Representative test results of serially diluted AFP using the CRISPR-powered PGM biosensing platform.