Table 1.

Ligand Evaluation for γ-C(sp³)−H Arylation of Aliphatic Ketones^{a, b}

^aConditions: 1a (0.1 mmol, 1.0 equiv), methyl 4-iodobenzoate (2.0 equiv), Pd(OAc)₂ (10 mol%), TDG1 (glycine, 30 mol%), L12 (60 mol%), AgTFA (3.0 equiv) and ClCH₂COOH (1.5 equiv) in HFIP (0. 5 mL), 120°C, under air, 48 h.

^bYield determined by ¹H NMR; CH₂Br₂ as internal standard.

^cLoading that gave the highest yield within a serial of concentrations.

^dRatio of mono:di.