Table 2.
Conditions: 1 (0.1 mmol, 1.0 equiv), methyl 4-iodobenzoate (2.0 equiv), Pd(OAc)2 (10 mol%), TDG1 (30 mol%), L12 (60 mol%), AgTFA (3.0 equiv) and ClCH2COOH (1.5 equiv) in HFIP (0. 5 mL), 120°C, under air, 48 h.
Isolated yields.
with ClCH2COOH (0.8 equiv) as additive
The reaction condition was modified with TDG1 (35 mol%), L10 (80 mol%) and ClCH2COOH (1.2 equiv) in HFIP (0.45 mL).