Regimen	ND/RR	≥25%↓ IgM;%	≥50%↓ IgM;%	≥90%↓ IgM;%	PFS, mo	Reference
ibrutinib	0/63	90.5	79.4	30.2	54%@5 years	61
ibrutinib	30/0	100	87	30	76%@48mo	64
Ibrutinib-R	34/41	93	73	26	82%@30mo	38
acalabrutinib	14/92	93/94	79/81	0/9	90/82@2 years	69
zanubrutinib	19/83	94	77	28	85%@18mo	71
Tirabrutinib	27		93	22	81% on therapy @ 24.8	72