Table 1.

A summary of the studies on gastric cancer using single-cell RNA sequencing.

Sample Type	Data Accession Number	Species	Contribution	Reference
GC, Normal, PC	GSE183904	Human	A high level of expression of INHBA and FAP in subpopulations of cancer-associated fibroblasts is associated with increased staging	(35)
DGC, Normal	GSE167297	Human	It is associated with an enrichment of CCL2 transcripts in inflammatory endothelial cells and fibroblasts in diffuse gastric cancer between the superficial and deep layer samples	(40)
NAG, CAG, IM, EGC	GSE134520	Human	A single-cell transcriptome atlas for gastric premalignant and early-malignant lesions, which spanned the cascade from gastritis to early gastric cancer	(43)
GC, Normal, CG	HRA000051	Human	Molecular evidences for potential transition from gastric chief cells into MUC6+TFF2+spasmolytic polypeptide expressing metaplasia	(44)
GC, CAG, IM, Normal	GSE150290	Human	Gastric cell landscape of intestinal gastric cancer and diffuse gastric cancer	(45)
HAS	HRA000077	Human	Adenocarcinomatous component and hepatocellular-like component of the same HAS tumor originate monoclonally, and HAS is likely to initiate from pluripotent precursor cells	(46)
HDGC	PRJEB41577	Mouse	The differentiation trajectory of squamous cells was shifted in HDGCs with Cdh1 inactivation	(47)
GC cell lines	GSE142750	Human	Heterogeneity of single cell transcriptome characteristics of gastric cancer cell lines	(48)
Ascites and cerebrospinal fluid	GSE140182	Human	Macrophages in malignant ascites of gastric cancer have strong non inflammatory properties	(49)
GC, Normal, PBMC, Blood	GSE172131	Human	Tumor infiltrating Tregs exhibit activated and effector states	(50)
AGC	EGAS00001004443	Human	Patient of gastric adenocarcinoma with peritoneal carcinomatosis was classified into two subtypes, the gastric-dominant and GI-mixed. Survival time for the former is shorter	(51)
GC, Normal	GSE158631	Human	Discovered some GC lymph node metastasis marker genes as well as potential gastric cancer evolutionary driving genes	(52)
GC, Normal, Metastasis	GSE163558	Human	Several subclusters of malignant epithelial cells were observed with invasion features, intraperitoneal metastasis propensity, epithelial–mesenchymal transition induced tumor stem cell phenotypes, or dormancy-like characteristics	(53)
CTCs	DRA011720	Human	A majority of gastric CTCs showed epithelial-mesenchymal transition	(54)
GC, Normal	CNP0001041	Human	The cytotoxicity and proliferation of T cells were decreased, immune pathways were downregulated, and angiogenesis pathways were activated in tumor cells and endothelial cells	(55)
GC, Normal	PRJEB45598	Human	TME remodeling was associated with response to first-line fluoropyrimidine and platinum chemotherapy	(56)
GC, Normal	PRJEB40416	Human	Compared to non-responders, responders of MSI-high patients treated with pembrolizumab had higher levels of T cells and NK cells	(57)
GC	GSE152888 GSE156725	Mouse	Immunotherapy for tumors can be guided by the deep immunological phenotyping	(58)