FIGURE 2.

Loss of p75NTR alters social behavior. (A) p75Atoh1-Cre mice show no difference in nose pokes directed at a mouse versus non-social object, unlike control mice which show significantly more mouse-directed nose pokes. (B) This genotype effect was not observed when examining time spent in the chambers housing the mouse or object. (C,D) p75Atoh1-Cre mice show no difference in nose pokes (C) and time in chamber (D) between novel and familiar mice, unlike control mice which show significantly more nose pokes and chamber time directed at the novel mouse. (E) p75Atoh1-CreERTM with TM show no difference in nose pokes directed at a mouse versus non-social object, unlike control mice. (F) This treatment effect was not observed when examining time spent in the different chambers. No effect of TM was observed on nose pokes (G) and time spent in chamber (H) between novel and familiar mice. (I–L) Novel object recognition test. (I) p75Atoh1-Cre mice show no difference in nose pokes directed at a novel versus familiar object, unlike control mice, which show a significant preference for the novel object. (J) This effect was not due to biased object exploration in the training phase. (K,L) No effect of TM was observed in novel object exploration in p75Atoh1-CreERTM mice. All data are expressed as the mean ± S.E.M. *Significantly different at p < 0.05. ⁺Significant main effect of object or novelty factor.