Table 4.
Hazard of death from all causes among CNS tumor patients (ages < 1 year) adjusted for demographics, year of dx, and treatment, by tumor type, SEER Registries, 1990–2015
| Variable | Category | High-grade glioma |
Low-grade glioma |
Ependymoma |
Medulloblastoma |
PNET/Pineal |
ATRT |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| aHR (95% CI) | P | aHR (95% CI) | P | aHR (95% CI) | P | aHR (95% CI) | P | aHR (95% CI) | P | aHR (95% CI) | P | ||
|
| |||||||||||||
| Age group | < 3 Month s | 1.26 (0.53, 2.99) | 0.607 | 10.27 (2.47, 42.68) | 0.001 | 0.29 (0.02, 3.65) | 0.338 | 2.77 (1.10, 6.99) | 0.031 | 3.69 (1.55, 8.80) | 0.003 | 0.62 (0.30, 1.29) | 0.204 |
| 3 Months to < 6 months | 0.44 (0.15, 1.28) | 0.131 | 1.12 (0.38, 3.26) | 0.842 | 2.02 (0.70, 5.83) | 0.195 | 1.29 (0.57, 2.92) | 0.547 | 2.54 (1.13, 5.72) | 0.024 | 0.93 (0.52, 1.65) | 0.794 | |
| 6 Months to < 12 months | Ref | Ref | Ref | Ref | Ref | Ref | |||||||
| Sex | Female | Ref | Ref | Ref | Ref | Ref | Ref | ||||||
| Male | 0.65 (0.30, 1.43) | 0.284 | 0.84 (0.32, 2.23) | 0.728 | 5.74 (1.68, 19.59) | 0.005 | 0.91 (0.47, 1.75) | 0.768 | 2.31 (1.23, 4.34) | 0.009 | 0.88 (0.52, 1.48) | 0.626 | |
| Race | White | Ref | Ref | Ref | Ref | Ref | Ref | ||||||
| Black | 1.59 (0.57, 4.47) | 0.379 | 1.24 (0.33, 4.68) | 0.747 | 8.40 (0.64, 110.06) | 0.105 | 3.61 (1.12, 11.66) | 0.032 | 3.34 (1.20, 9.29) | 0.021 | 0.94 (0.40, 2.24) | 0.898 | |
| Other | 0.17 (0.02, 1.46) | 0.106 | 1.67 (0.20, 14.01) | 0.637 | 2.28 (0.53, 9.79) | 0.269 | 1.57 (0.58, 4.25) | 0.377 | 1.58 (0.50, 4.99) | 0.435 | 1.47 (0.68, 3.20) | 0.326 | |
| Unknown | – | – | – | – | – | – | – | – | – | – | 0.27 (0.03, 2.23) | 0.226 | |
| Ethnicity | Non-Hispanic | Ref | Ref | Ref | Ref | Ref | Ref | ||||||
| Hispanic | 2.35 (1.01, 5.45) | 0.046 | 2.24 (0.82, 6.13) | 0.117 | 5.71 (1.72, 18.92) | 0.004 | 1.87 (0.93, 3.79) | 0.08 | 1.48 (0.79, 2.78) | 0.221 | 1.09 (0.62, 1.93) | 0.77 | |
| Year of diagnosis | 1990–1994 | 0.41 (0.10, 1.72) | 0.223 | 0.61 (0.06, 6.71) | 0.688 | 14.10 (2.26, 87.85) | 0.005 | 3.95 (1.21, 12.82) | 0.022 | 0.67 (0.20, 2.24) | 0.517 | – | – |
| 1995–1999 | 0.69 (0.20, 2.35) | 0.548 | 1.49 (0.23, 9.50) | 0.675 | 2.87 (0.21, 39.22) | 0.429 | 3.04 (1.00, 9.21) | 0.049 | 0.38 (0.11, 1.25) | 0.111 | – | – | |
| 2000–2004 | 1.50 (0.55, 4.12) | 0.428 | 1.16 (0.27, 4.97) | 0.839 | 2.86 (0.62, 13.09) | 0.177 | 3.15 (1.06, 9.39) | 0.039 | 0.53 (0.18, 1.60) | 0.258 | 0.99 (0.51, 1.93) | 0.979 | |
| 2005–2009 | 2.55 (0.82, 7.94) | 0.107 | 1.37 (0.35, 5.32) | 0.65 | 1.03 (0.16, 6.73) | 0.974 | 0.44 (0.10, 1.98) | 0.283 | 0.41 (0.13, 1.28) | 0.124 | 0.83 (0.46, 1.49) | 0.527 | |
| 2010–2015 | Ref | Ref | Ref | Ref | Ref | Ref | |||||||
| Surgery performed | Yes | Ref | Ref | Ref | Ref | Ref | Ref | ||||||
| No | 1.05 (0.42, 2.66) | 0.911 | 0.64 (0.17, 2.37) | 0.506 | 18.38 (3.00, 112.46) | 0.002 | 2.13 (0.84, 5.41) | 0.11 | 1.86 (0.88, 3.91) | 0.102 | 3.41 (1.42, 8.19) | 0.006 | |
| Unknown | – | – | – | – | – | – | – | – | – | – | – | – | |
| Radiation administered | Yes | – | Ref | Ref | Ref | Ref | Ref | ||||||
| No | – | 0.57 (0.07, 4.87) | 0.611 | 1.09 (0.30, 4.05) | 0.893 | 5.33 (1.16, 24.51) | 0.032 | 3.44 (0.80, 14.81) | 0.097 | 3.57 (1.61, 7.91) | 0.002 | ||
| Unknown | – | – | – | – | – | 2.41 (0.18, 32.67) | 0.508 | – | – | – | – | ||
| Chemotherapy administered | Yes | Ref | Ref | Ref | Ref | Ref | Ref | ||||||
| No/Unknown | 4.18 (1.91, 9.15) | <.001 | 0.99 (0.39, 2.54) | 0.986 | 1.57 (0.54, 4.52) | 0.405 | 2.68 (1.17, 6.15) | 0.02 | 7.64 (2.21, 26.46) | 0.001 | 2.55 (1.39, 4.70) | 0.003 | |
| Time-dependent covariates | Chemotherapy * Time | 0.70 (0.56, 0.89) | 0.003 | ||||||||||