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. 2023 Jun 8;18(6):e0286863. doi: 10.1371/journal.pone.0286863

Table 4. Associations of low and high rates in induction of labor in MCNs with primary outcomes, in comparison with MCNs with a moderate induction of labor rate in (multilevel modelling).

OR (95% CI)
Q1 (low)
p-value OR (95% CI)
Q4 (high)
p-value variance
UNPLANNED CAESAREAN SECTION
crude OR
(no modelling) 0.84 (0.81–0.87) < 0.001 1.07 (1.03–1.11) < 0.001 NA
1.Empty model
(fixed effect multilevel, no confounders) 0.83 (0.72–0.95) 0.006 1.02 (0.89–1.17) 0.777 0.053
2.Sociodemographic confounders
2a: model 1 + SES and Ethnic background 0.83 (0.72–0.95) 0.008 1.01 (0.88–1.16) 0.885 0.057
2b: model 1 + SES and Ethnic background + maternal age 0.82 (0.71–0.95) 0.007 1.01 (0.88–1.17) 0.874 0.061
3.Sociodemographic + pregnancy characteristics
3a: model 2b + pregnancy complications 0.83 (0.72–0,96) 0.010 0.99 (0.88–1.16) 0.896 0.062
3b: model 2b + macrosomia (birthweight ≥ 4500g) 0.82 (0.71–0.95) 0.006 1.02 (0.89–1.18) 0.747 0.062
3c: model 2b + pregnancy complications + macrosomia 0.83 (0.72–0.95) 0.009 1.00 (0.87–1.16) 0.967 0.062
MATERNAL COMPOSITE
crude OR
(no modelling) 0.92 (0.90–0.94) < 0.001 1.02 (0.998–1.05) 0.073 NA
1.Empty model
(fixed effect multilevel, no confounders) 0.93 (0.85–1.01) 0.103 1.03 (0.94–1.12) 0.526 0.023
2.Sociodemographic confounders
2a: model 1 + SES and Ethnic background 0.93 (0.85–1.01) 0.087 1.03 (0.94–1.12) 0.513 0.023
2b: model 1 + SES and Ethnic background + maternal age 0.92 (0.84–1.01) 0.068 1.03 (0.94–1.13) 0,473 0.024
3.Sociodemographic + pregnancy characteristics
3a: model 2b + pregnancy complications 0.92 (0.84–1.01) 0.085 1.02 (0.94–1.12) 0.608 0.025
3b: model 2b + macrosomia (birthweight ≥ 4500g) 0.92 (0.84–1.01) 0.069 1.04 (0.95–1.14) 0.387 0.024
3c: model 2b + pregnancy complications + macrosomia 0.92 (0.84–1.01) 0.085 1.03 (0.94–1.13) 0.508 0.025
NEONATAL COMPOSITE
crude OR
(no modelling) 0.93 (0.84–1.04) 0.210 1.14 (1.03–1.28) 0.016 NA
1.Empty model
(fixed effect multilevel, no confounders) 0.999 (0.67–1.50) 0.998 0.97 (0.64–1.47) 0.869 0.501
2.Sociodemographic confounders
2a: model 1 + SES and Ethnic background 1.01 (0.67–1.52) 0.967 0.96 (0.63–1.47) 0.864 0.500
2b: model 1 + SES and Ethnic background + maternal age 1.01 (0.67–1.52) 0.971 0.99 (0.63–1.47) 0.870 0.494
3.Sociodemographic including NICU availability
3: model 2b + NICU availability 0.96 (0.76–1.22) 0.748 0.86 (0.67–1.10) 0.220 0.124
4.Sociodemographic + pregnancy characteristics
4a: model 3 + pregnancy complications 0.96 (0.76–1.22) 0.757 0.86 (0.67–1.10) 0.218 0.124
4b: model 3 + SGA (birthweight <p3) 0.97 (0.77–1.22) 0.761 0.86 (0.67–1.09) 0.215 0.123
4c: model 3 + SGA + pregnancy complications 0.97 (0.77–1.22) 0.769 0.86 (0.67–1.09) 0.212 0.123

OR: odds ratio; CI: confidence interval