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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Stroke. 2022 Nov 2;54(1):245–254. doi: 10.1161/STROKEAHA.122.040401

Fig. 3: FTO overexpression ameliorated post-stroke motor dysfunction and depression-like behavior in mice of both sexes.

Fig. 3:

Motor function was assessed by rotarod (A and B) and beam walk (C and D) tests in control AAV9 and FTO AAV9 treated mice at 1 day before occlusion and on days 1, 3, 5, and 7 of reperfusion after 1 h transient MCAO. Data are mean±SEM (n=16/group). *p<0.05 compared with the control AAV9 treated group by two-way repeated-measures ANOVA (Sidak post hoc correction). Depression-like behavioral assessment in sham, control AAV9 and FTO AAV9 treated male (E) and female mice (F) by tail-suspension test at 25 days of reperfusion after 1 h transient MCAO. Data are mean±SEM (n=10/group for males and n=7–8/group for females). *p<0.05 compared with sham and #p<0.05 compared with control AAV9 ischemia group, by Mann-Whitney U test.