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. Author manuscript; available in PMC: 2023 Oct 1.
Published in final edited form as: J Pediatr. 2022 Jun 27;249:59–66.e1. doi: 10.1016/j.jpeds.2022.06.023

Table V.

Adjusted PRs (postfortification to prefortification periods) of spina bifida cases by lesion level by maternal race/ethnicity, maternal age, and infant sex

All spina bifida cases*
Upper lesion level cases
Lower lesion level cases
Characteristics APR, 95% CI P value APR, 95% CI P value APR, 95% CI P value
Total 0.77 (0.69-0.86) 0.28 (0.23-0.33) 0.93 (0.81-1.07)
Maternal race/ethnicity
 White, non-Hispanic 0.74 (0.62-0.87) Ref 0.21 (0.17-0.27) Ref 0.91 (0.79-1.06) Ref
 Black, non-Hispanic 1.23 (1.10-1.37) <.0001 0.64 (0.46-0.89) <.0001 1.42 (1.25-1.60) <.0001
 Hispanic 0.81 (0.72-0.90) 0.10 0.31 (0.26-0.38) 0.003 0.93 (0.83-1.05) 0.67
Maternal age
 <20 y 0.77 (0.62-0.96) 0.65 0.68 (0.45-1.02) <.0001 0.77 (0.60-0.97) 0.04
 20-34 y 0.79 (0.68-0.94) Ref 0.23 (0.20-0.26) Ref 0.98 (0.82-1.16) Ref
 35+ y 0.93 (0.67-1.30) 0.40 0.45 (0.18-1.13) 0.12 1.08 (0.86-1.35) 0.58
Infant sex
 Female 0.72 (0.58-0.89) Ref 0.28 (0.19-0.42) Ref 0.85 (0.70-1.04) Ref
 Male 0.81 (0.69-0.95) .46 0.28 (0.22-0.36) .98 0.99 (0.78-1.26) .39

APR, adjusted PR (ratio of prevalence postfortification to prevalence prefortification, adjusted for state program).

P values are for the pairwise testing of APR against each referent group for maternal race/ethnicity, maternal age, or infant sex.

*

All cases include unknown lesion level.