Figure 5.

The EBV genome tethered in proximity to TASOR and strengthened loop formation between the TASOR enhancer and promoter. Histone ChIP-seq and HiC-seq interaction at TASOR (A), PPHLN1 (B) and MPP8 (C) gene loci in MKN7 and MKN7_EBVi cells. From top to bottom: EBVIRs (gray bar) illustrated by 4C-seq with the EBV genome as bait; tracks showing H3K9me3, H3K27me3, H3K4me3, H3K4me1, H3K27ac signal; and HiC-seq loops for MKN7 and MKN7_EBVi. Interaction strength was demonstrated by the depth of the loop. Promoter, pink shadow; enhancer, green shadow.