Figure 1.

Circular dichroism spectra of the different DNA·RNA duplexes here investigated. Reference conformations are reported by dashed lines: the red dashed one indicates the canonical B-conformation of DNA·DNA duplex, the purple dashed one describes the canonical A-conformation typical of the RNA·RNA duplex while the dashed green line represents the non-A/non-B conformation associated with the hybrid DNA·RNA duplexes. RpDNA·RNA is shown as pink line, SpDNA·RNA in blue, SpRpDNA·RNA in yellow and RpSpDNA·RNA in black. See Methods for the experimental conditions.