Table 2.

Comparison of relative Tm and folding free energies for different hybrids determined experimentally and relative free energy estimated from our mesoscopic model. Values are compared to the pro-Rp S-substituted system. Roman means standard phosphate linkages, underlined characters stand for the R PS linker (Rp) and italics refers to S PS linker (Sp). ΔTm are in degrees and free energy values are in kJ/mol before the slash and kcal/mol after the slash. All values are referred to the corresponding all Rp hybrid of the same sequence (31). Error of our predictor falls in the range of 10%. Absolute melting temperatures for the hybrids considered here and the associated parameters for folding thermodynamics are shown in Supplementary Table S2