Figure 8.

Schematic model of DNA damage response that occurs in oocytes during meiosis I. After DNA damage, spindle microtubules rapidly shrink and are stabilized. Moreover, DSBs induce the PLK1 inactivation at spindle poles, which in turn causes CIP2A dephosphorylation. Once dephosphorylated, CIP2A complexed with p-MDC1 and p-TOPBP1 at spindle poles moves along spindle microtubules and is recruited to chromosomes through kinetochores and centromeres, which further ensures the recruitment of downstream repair factors, including BRCA1 and 53BP1, and subsequent DNA repair during oocyte meiosis.