Table 1.

Discovery single-variant association analysis for age-related hearing loss traits.

CHR	SNP	EA	EAF	Gene	H-aid			H-diff			H-noise			H-both
					Beta (OR)	SE	P	Beta (OR)	SE	P	Beta (OR)	SE	P	Beta (OR)	SE	P
5	rs537688122	G	6.65 × 10−4	PDCD6	1.99 (7.3)	0.29	2.25 × 10−10	1.32 (3.7)	0.17	1.12 × 10−15	1.04 (2.8)	0.16	5.50 × 10−11	1.27 (3.6)	0.18	1.02 × 10−12
5	rs549592074	C	5.58 × 10−4	PDCD6	1.99 (7.3)	0.32	1.95 × 10−8	1.35 (3.9)	0.18	7.05 × 10−14	1.07 (2.9)	0.18	6.69 × 10−10	1.28 (3.6)	0.19	5.52 × 10−11
5	rs571370281	G	7.04 × 10−4	PDCD6	1.92 (6.8)	0.28	6.02 × 10−10	1.33 (3.8)	0.16	1.14 × 10−16	1.03 (2.8)	0.16	2.26 × 10−11	1.29 (3.6)	0.17	9.66 × 10−14
6	rs1574430	C	6.09 × 10−1	SLC22A7										0.06 (1.1)	0.01	2.77 × 10−8
6	rs2242416	G	6.09 × 10−1	CRIP3										0.06 (1.1)	0.01	2.60 × 10−8
6	rs121912560	G	7.63 × 10−5	MYO6	5.48 (239.8)	1.12	1.79 × 10−10	3.54 (34.5)	0.90	3.41 × 10−9				3.73 (41.7)	0.90	3.76 × 10−10

Genome-wide-significant variants (p < 5 × 10⁻⁸) with hearing aid (H-aid), hearing difficulty (H-diff), hearing difficulty with background noise (H-noise), and the combined hearing trait (H-both) in the analysis of the discovery sample of white-European individuals from the UK Biobank. The p-values for replicated associations (empirical p-values <0.05 adjusting for variants and traits brought to replication) are shown in bold (See Table S4 for replication analytical and empirical values).

CHR chromosome, EA effect allele, EAF effect allele frequency, OR odds ratio, SE standard error, P p-value.