Table 2.
Mega-sample single variant association analysis with age-related hearing loss traits.
| CHR | SNP | EA | EAF | Gene | H-aid | H-diff | H-noise | H-both | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta (OR) | SE | P | Beta (OR) | SE | P | Beta (OR) | SE | P | Beta (OR) | SE | P | |||||
| 1 | rs11589562 | C | 0.424 | MAST2 | −0.05 (0.95) | 0.01 | 2.25 × 10−8 | |||||||||
| 1 | rs2275426 | A | 0.431 | MAST2 | −0.05 (0.95) | 0.01 | 3.39 × 10−8 | |||||||||
| 1 | rs1707336 | G | 0.435 | MAST2 | −0.05 (0.95) | 0.01 | 3.63 × 10−8 | |||||||||
| 1 | rs1707304 | A | 0.436 | PIK3R3 | −0.05 (0.95) | 0.01 | 2.34 × 10−8 | −0.05 (0.95) | 0.01 | 3.30 × 10−8 | ||||||
| 5 | rs537688122a | G | 7 × 10−4 | PDCD6 | 1.79 (6.0) | 0.25 | 7.06 × 10−11 | 1.35 (3.9) | 0.14 | 1.04 ×10−21 | 1.1 (3.0) | 0.14 | 4.96×10−16 | 1.32 (3.8) | 0.15 | 1.11 × 10−18 |
| 5 | rs549592074a | C | 6 × 10−4 | PDCD6 | 1.70 (5.5) | 0.28 | 2.48 × 10−8 | 1.37 (3.9) | 0.16 | 5.19 × 10−19 | 1.08 (3.0) | 0.15 | 2.19×10−13 | 1.32 (3.8) | 0.16 | 6.63 × 10−16 |
| 5 | rs571370281 | G | 7 × 10−4 | PDCD6 | 1.71 (5.5) | 0.24 | 1.34 × 10−10 | 1.31 (3.7) | 0.14 | 1.00 × 10−21 | 1.04 (2.8) | 0.14 | 1.83×10−15 | 1.28 (3.6) | 0.15 | 8.00 × 10−19 |
| 5 | rs7714670 | C | 0.467 | ARHGEF28 | 0.11 (1.1) | 0.02 | 9.99 × 10−9 | 0.05 (1.05) | 0.01 | 1.63 × 10−9 | 0.05 (1.05) | 0.01 | 1.06 × 10−8 | |||
| 5 | rs11949860 | A | 0.462 | ARHGEF28 | 0.11 (1.1) | 0.02 | 3.87 × 10−8 | 0.05 (1.05) | 0.01 | 9.92 × 10−9 | ||||||
| 5 | rs35525194 | G | 0.471 | ARHGEF28 | 0.11 (1.1) | 0.02 | 7.03 × 10−9 | 0.05 (1.05) | 0.01 | 2.19 × 10−9 | 0.05 (1.05) | 0.01 | 1.21 × 10−8 | |||
| 5 | rs6453022 | A | 0.501 | ARHGEF28 | 0.11 (1.1) | 0.02 | 7.30 × 10−9 | 0.05 (1.05) | 0.01 | 2.75 × 10−10 | 0.06 (1.06) | 0.01 | 4.13 × 10−10 | |||
| 5 | rs7716253 | C | 0.524 | ARHGEF28 | 0.11 (1.1) | 0.02 | 8.82 × 10−9 | 0.05 (1.05) | 0.01 | 6.29 × 10−9 | 0.05 (1.05) | 0.01 | 2.19 × 10−8 | |||
| 5 | rs2973549 | A | 0.478 | ARHGEF28 | 0.11 (1.1) | 0.02 | 1.23 × 10−8 | 0.05 (1.05) | 0.01 | 2.22 × 10−8 | ||||||
| 5 | rs2973548 | T | 0.478 | ARHGEF28 | 0.11 (1.1) | 0.02 | 2.61 × 10−8 | 0.05 (1.05) | 0.01 | 4.90 × 10−8 | ||||||
| 6 | rs146694394 | T | 0.005 | SYNJ2 | 0.33 (1.4) | 0.06 | 1.72 × 10−8 | |||||||||
| 6 | rs1574430 | C | 0.608 | SLC22A7 | 0.05 (1.05) | 0.01 | 2.10 × 10−10 | 0.05 (1.05) | 0.01 | 4.22×10−10 | 0.06 (1.06) | 0.01 | 8.06 × 10−12 | |||
| 6 | rs2242416 | G | 0.606 | CRIP3 | 0.05 (1.05) | 0.01 | 2.25 × 10−10 | 0.05 (1.05) | 0.01 | 3.89×10−10 | 0.06 (1.06) | 0.01 | 8.13 × 10−12 | |||
| 6 | rs2254303 | A | 0.606 | CRIP3 | 0.05 (1.05) | 0.01 | 1.49 × 10−9 | 0.05 (1.05) | 0.01 | 1.90×10−9 | 0.06 (1.06) | 0.01 | 3.88 × 10−11 | |||
| 6 | rs765264064a | C | 6 × 10−5 | FILIP1 | 3.01(20.3) | 0.48 | 2.81 × 10−9 | |||||||||
| 6 | rs121912560a | G | 0.005 | MYO6 | 5.28(196.3) | 0.98 | 5.15 × 10−14 | 3.73 (41.9) | 0.87 | 2.26 × 10−12 | 3.26 (26.1) | 0.86 | 1.09×10−9 | 3.86 (47.7) | 0.88 | 8.72 × 10−13 |
| 7 | rs2286276 | T | 0.284 | TBL2 | 0.05 (1.05) | 0.01 | 4.66 × 10−8 | |||||||||
| 7 | rs61010704 | G | 0.283 | MLXIPL | 0.05 (1.05) | 0.01 | 3.16 × 10−8 | 0.05 (1.05) | 0.01 | 2.72 × 10−8 | ||||||
| 22 | rs371997714 | G | 0.293 | BAIAP2L2 | 0.05 (1.05) | 0.01 | 1.40 × 10−8 | |||||||||
| 22 | rs36062310 | A | 0.043 | KLHDC7B | 0.12 (1.1) | 0.02 | 1.32 × 10−9 | 0.12 (1.3) | 0.02 | 6.66 × 10−9 | ||||||
Genome-wide significant variants (p < 5 × 10−8) with hearing aid (H-aid), hearing difficulty (H-diff), hearing difficulty with background noise (H-noise) and the combined hearing trait (H-both) in the analysis of the mega-sample of white-European individuals from the UK Biobank. The p-values for replicated associations (empirical p-values <0.05 adjusting for variants and traits brought to replication) are shown in bold (See Table S4 for replication analytical and empirical values).
CHR chromosome, EA effect allele, EAF effect allele frequency, OR odds ratio, SE standard error, P p-value.
aVariant not found present in the replication sample.