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. 2023 Jun 8;13:9297. doi: 10.1038/s41598-023-35765-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Molecular docking of silvestrol to select eIF4A variants. (A) Aromatic or aromatic-like aa residues at position 163 such as Phe or His, respectively, allow for the establishment of stable π–π-stacking interactions with rocaglates. (B) Substitutions with short chain aa residues such as Val allow for hydrophobic interactions with rocaglates that can to some extent compensate for the lack of π–π-stacking interactions. (C) Long aliphatic side chains such as Leu or Ile sterically preempt the formation of stable hydrophobic interactions, rendering the corresponding eIF4As resistant to rocaglate mediated clamping of the eIF4A:RNA complex.