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. 2023 Jun 8;14:3368. doi: 10.1038/s41467-023-39118-9

Fig. 7. Effects of nomilin on healthspan in D-galactose-treated PXR knockout mice.

Fig. 7

a Passing time in beam balance test (n = 8/group). b T-climbing down in pole test (n = 8/group). c Dwelling time on rotating rod test (n = 8/group). d Number of falls from the rotating rod (n = 8/group). Hind limb stride length (e, n = 8/group) and hind limb stance width (f, n = 8/group) in gait analysis. g Proportion of the number of times entering new arm in the Y maze (n = 8/group). h Proportion of time spent in exploring new arm in Y maze (n = 8/group). i, j Apoptotic cells and the quantification of apoptotic cells in CA1 of the hippocampus (n = 5/group). k, l Apoptotic cells and the quantification of apoptotic cells in CA3 of the hippocampus (n = 5/group). m H&E staining of liver sections. n Inflammatory infiltration area per mm2 liver sections (n = 5/group). The mice were treated with D-galactose (125 mg/kg/day) and nomilin for 7 weeks. The data were shown as mean ± SEM. p-values were determined by one-way ANOVA test (ah, j, l, m). ###p < 0.001 vs the control group; ***p < 0.001 vs the D-galactose group.