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. 2023 Jun 8;14(6):351. doi: 10.1038/s41419-023-05869-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Heatmap of differentially expressed genes between A549-ORI and A549-PTX cells by RNA-Seq. B The top 15 enriched signaling pathways based on the 2914 upregulated genes in A549-PTX cells. C FPKM values of genes in the complement and coagulation cascade pathways. D C3 expression at the mRNA and protein levels in A549-ORI and A549-PTX cells measured by qRT‒PCR and immunoblotting (IB) assays. Data represent the mean ± SD, n = 3, two-tailed Student’s t test. E Kaplan‒Meier survival analysis for the relationship between the survival rate of chemotherapy-treated or nonchemotherapy-treated lung cancer patients and the expression of C3 (by log-rank). HR, hazard ratio. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001.