Table 3.

shows results of time-dependent reclassification analysis for the clinical, radiomics, and combined clinical-radiomic model based on repeated nested cross validation results (test sets within the outer folds)

Models to compare	Improvement in sensitivitiy	Improvement in specificity	Integrated discrimination improvement index	p-value	Net reclassification improvement index	p-value
M0: clinical signature M1: radiomic signature	0.263	0.083	0.346	0.221	0.397	<0.005
M0: clinical signature M1: clinical-radiomic signature	0.778	−0.012	0.766	0.027	0.726	<0.005
M0: clinical-radiomic signature M1: radiomic signature	−0.515	0.095	−0.420	0.074	−0.315	<0.005