Table 4.
Concordance rates between SPIO and Tc99
| Breast procedure | All SLNs concordant (n, %) | At least one SLN concordant (n, %) | |||
|---|---|---|---|---|---|
| SPIO and Tc99 with or without BD | SPIO and Tc99 without BD | SPIO and Tc99 with BD | Difference (%, 95% CI) | p* | |
| WLE (n = 11) | 7 (68.6%) | 10 (90.9%) | 11 (100.0%) | 9.1% (− 16.9, 35.2) | 1.000 |
| OPBCT (n = 24) | 2 (8.3%) | 2 (8.3%) | 8 (33.3%) | 25.0% (3.5, 46.5) | 0.031 |
| Mastectomy (n = 20) | 3 (15.0%) | 4 (20.0%) | 6 (30.0%) | 10% (− 8.1, 28.1) | 0.500 |
| Total (n = 55) | 12 (21.8%) | 16 (29.1%) | 25 (45.5%) | 16.4% (− 4.8, 28.0) | 0.008 |
| p† | < 0.001 | < 0.001 | < 0.001 | ||
Absolute numbers refer to patients
BD blue dye, CI confidence interval, OPBCT oncoplastic breast-conserving therapy, SPIO superparamagnetic iron oxide nanoparticles, Tc99 Technetium 99, WLE wide local excision
*p-value is two-sided and refers to McNemar’s test for paired proportions, denoting whether the difference in concordance with or without the definition of BD is statistically significant, †p-value is two-sided and refers to Fisher’s exact test, denoting whether concordance rates vary significantly per type of breast procedure