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. 2022 Dec 9;53(13):6261–6270. doi: 10.1017/S0033291722003579

Fig. 2.

Fig. 2.

Secondary analyses of change in depression severity based on functional connectivity patterns. (a) Initial secondary analyses, after adjusting for regional gray matter volumes, tested for a moderating effect of seed-to-seed FC on the change in depression severity in response to treatment assignment (Time by treatment by FC interaction term; t = −2.38, df = 326, p = 0.0184). Higher FC between the right mPFC and left rACC (DMN) is associated with better clinical outcomes for individuals assigned to escitalopram, but worse outcomes for those assigned to placebo. (b) After removing the three-way interaction term, after adjusting for regional gray matter volumes, higher FC between the PCC and left hippocampus was associated with better clinical response over time (Time by treatment interaction term, t = −2.07, df = 327, p = 0.0388). No other seed-to-seed FC measure exhibited statistically significant three-way or treatment by time interaction terms. FC, functional connectivity; mPFC, medial prefrontal cortex; rACC, rostral anterior cingulate cortex; PCC, posterior cingulate cortex; x-axis = connectivity beta values; y-axis = MADRS score (0 to 60 scale). Time displayed in weeks.