TABLE 4.
Associations between SLC17A8, SHANK1, TRPV1, TRPV3 and TRPM8 gene polymorphisms and the risk of migraine by aura.
| SNPs/genotypes/genetic models | Control No. (%) | MA | MO | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No. (%) | OR (95% CI) | p | ORadj (95% CI) | p | No. (%) | OR (95% CI) | p | ORadj (95% CI) | p | ||
| SLC17A8-rs11110359 G>A | |||||||||||
| GG | 462 (77.00) | 42 (82.35) | ref | ref | 141 (70.50) | ref | ref | ||||
| GA | 122 (20.33) | 9 (17.65) | 0.81 (0.36–1.64) | 0.584 | 0.81 (0.34–1.744) | 0.604 | 54 (27.00) | 1.45 (1.00–2.10) | 0.050 | 1.56 (1.03–2.34) | 0.034 |
| AA | 16 (2.67) | 0 (0.00) | — | — | — | — | 5 (2.50) | 1.02 (0.33–2.67) | 0.964 | 1.17 (0.35–3.28) | 0.785 |
| Dominant model | 0.72 (0.32–1.45) | 0.382 | 0.72 (0.30–1.538) | 0.416 | 1.40 (0.98–2.00) | 0.065 | 1.51 (1.02–2.24) | 0.040 | |||
| Recessive model | 0.84 (0.37–1.70) | 0.646 | 0.84 (0.35–1.808) | 0.669 | 1.45 (1.00–2.09) | 0.049 | 1.55 (1.03–2.33) | 0.036 | |||
| Additive model | 1.19 (0.59–2.67) | 0.646 | 1.19 (0.55–2.837) | 0.669 | 0.69 (0.48–1.00) | 0.049 | 0.65 (0.43–0.98) | 0.036 | |||
| SLC17A8-rs11568537 A>C | |||||||||||
| AA | 404 (67.33) | 31 (60.78) | ref | ref | 142 (71.00) | ref | ref | ||||
| AC | 167 (27.83) | 16 (31.37) | 1.25 (0.65–2.31) | 0.490 | 1.29 (0.63–2.556) | 0.479 | 55 (27.50) | 0.94 (0.65–1.34) | 0.723 | 0.94 (0.63–1.37) | 0.737 |
| CC | 29 (4.83) | 4 (7.84) | 1.80 (0.51–4.94) | 0.299 | 1.72 (0.43–5.475) | 0.396 | 3 (1.50) | 0.29 (0.07–0.85) | 0.046 | 0.22 (0.05–0.70) | 0.021 |
| Dominant model | 0.60 (0.22–2.07) | 0.352 | 0.63 (0.20–2.463) | 0.457 | 3.34 (1.17–14.03) | 0.049 | 4.40 (1.42–19.57) | 0.023 | |||
| Recessive model | 1.19 (0.62–2.16) | 0.590 | 1.23 (0.61–2.411) | 0.554 | 0.98 (0.68–1.40) | 0.927 | 1.00 (0.67–1.46) | 0.978 | |||
| Additive model | 0.84 (0.46–1.60) | 0.590 | 0.81 (0.42–1.652) | 0.554 | 1.02 (0.71–1.46) | 0.927 | 1.01 (0.69–1.49) | 0.978 | |||
| SHANK1-rs3745521 A>G | |||||||||||
| AA | 173 (28.83) | 12 (23.53) | ref | ref | 68 (34.00) | ref | ref | ||||
| AG | 293 (48.83) | 21 (41.18) | 1.03 (0.50–2.22) | 0.930 | 0.93 (0.42–2.12) | 0.857 | 93 (46.50) | 0.81 (0.56–1.17) | 0.251 | 0.70 (0.47–1.05) | 0.083 |
| GG | 134 (22.33) | 18 (35.29) | 1.94 (0.91–4.26) | 0.090 | 1.78 (0.77–4.24) | 0.184 | 39 (19.50) | 0.74 (0.47–1.16) | 0.194 | 0.63 (0.38–1.03) | 0.067 |
| Dominant model | 0.53 (0.29–0.98 | 0.038 | 0.54 (0.28–1.07) | 0.070 | 1.19 (0.80–1.79) | 0.400 | 1.28 (0.84–1.98) | 0.267 | |||
| Recessive model | 0.73 (0.41–1.30) | 0.295 | 0.68 (0.36–1.28) | 0.241 | 0.91 (0.66–1.26) | 0.567 | 0.85 (0.60–1.20) | 0.361 | |||
| Additive model | 1.36 (0.77–2.47) | 0.295 | 1.46 (0.78–2.79) | 0.241 | 1.10 (0.80–1.52) | 0.567 | 1.18 (0.83–1.66) | 0.361 | |||
| TRPV1-rs8065080 C>T | |||||||||||
| CC | 212 (35.33) | 22 (43.14) | ref | ref | 73 (36.50) | ref | ref | ||||
| TC | 287 (47.83) | 23 (45.10) | 0.77 (0.42–1.43) | 0.407 | 0.64 (0.32–1.27) | 0.204 | 105 (52.50) | 1.06 (0.75–1.51) | 0.732 | 1.01 (0.69–1.47) | 0.962 |
| TT | 101 (16.83) | 6 (11.77) | 0.57 (0.21–1.37) | 0.241 | 0.52 (0.17–1.37) | 0.209 | 22 (11.00) | 0.63 (0.37–1.06) | 0.092 | 0.55 (0.31–0.97) | 0.043 |
| Dominant model | 1.52 (0.68–4.05) | 0.352 | 1.52 (0.62–4.39) | 0.394 | 1.64 (1.02–2.74) | 0.049 | 1.82 (1.09–3.17) | 0.027 | |||
| Recessive model | 0.90 (0.50–1.59) | 0.707 | 0.77 (0.40–1.44) | 0.412 | 1.21 (0.88–1.66) | 0.253 | 1.19 (0.84–1.69) | 0.327 | |||
| Additive model | 1.12 (0.63–2.00) | 0.707 | 1.31 (0.69–2.50) | 0.412 | 0.83 (0.60–1.14) | 0.253 | 0.84 (0.59–1.19) | 0.327 | |||
| TRPV3-rs7217270 G>A | |||||||||||
| GG | 535 (89.17) | 44 (86.28) | ref | ref | 166 (83.00) | ref | ref | ||||
| AG | 62 (10.33) | 7 (13.73) | 1.37 (0.55–3.00) | 0.460 | 1.19 (0.43–2.92) | 0.716 | 31 (15.50) | 1.61 (1.00–2.55) | 0.044 | 1.58 (0.94–2.60) | 0.077 |
| AA | 3 (0.50) | 0 (0.00) | — | — | — | — | 3 (1.50) | 3.22 (0.59–17.56) | 0.154 | 2.66 (0.46–15.78) | 0.258 |
| Dominant model | 1.31 (0.52–2.86) | 0.528 | 1.16 (0.42–2.82) | 0.761 | 1.69 (1.07–2.63) | 0.023 | 1.61 (0.98–2.60) | 0.056 | |||
| Recessive model | 1.38 (0.55–3.02) | 0.452 | 1.20 (0.43–2.93) | 0.712 | 1.59 (0.99–2.52) | 0.050 | 1.56 (0.94–2.58) | 0.083 | |||
| Additive model | 0.72 (0.33–1.82) | 0.452 | 0.84 (0.34–2.32) | 0.712 | 0.63 (0.40–1.01) | 0.050 | 0.64 (0.39–1.07) | 0.083 | |||
| TRPM8-rs17862920 C>T | |||||||||||
| CC | 321 (53.50) | 31 (60.78) | ref | ref | 126 (63.00) | ref | ref | ||||
| CT | 237 (39.50) | 16 (31.37) | 0.70 (0.37–1.29) | 0.263 | 0.70 (0.34–1.39) | 0.316 | 66 (33.00) | 0.71 (0.50–1.00) | 0.049 | 0.77 (0.53–1.12) | 0.169 |
| TT | 42 (7.00) | 4 (7.84) | 0.99 (0.28–2.65) | 0.980 | 1.00 (0.25–3.15) | 0.996 | 8 (4.00) | 0.49 (0.21–1.01) | 0.071 | 0.57 (0.23–1.25) | 0.183 |
| Dominant model | 0.88 (0.34–3.03) | 0.822 | 0.88 (0.29–3.43) | 0.834 | 1.81 (0.88–4.21) | 0.134 | 1.59 (0.73–3.89) | 0.268 | |||
| Recessive model | 0.70 (0.37–1.27) | 0.255 | 0.70 (0.34–1.37) | 0.307 | 0.75 (0.54–1.05) | 0.101 | 0.81 (0.56–1.16) | 0.258 | |||
| Additive model | 1.43 (0.79–2.70) | 0.255 | 1.43 (0.73–2.93) | 0.307 | 1.33 (0.95–1.86) | 0.101 | 1.24 (0.86–1.788) | 0.258 | |||
| TRPM8-rs7577262 G>A | |||||||||||
| GG | 220 (36.67) | 27 (52.94) | ref | ref | 89 (44.50) | ref | ref | ||||
| GA | 294 (49.00) | 17 (33.33) | 0.47 (0.25–0.88) | 0.019 | 0.55 (0.27–1.07) | 0.081 | 88 (44.00) | 0.74 (0.53–1.04) | 0.085 | 0.81 (0.56–1.17) | 0.257 |
| AA | 86 (14.33) | 7 (13.73) | 0.66 (0.26–1.50) | 0.354 | 0.54 (0.19–1.36) | 0.216 | 23 (11.50) | 0.66 (0.39–1.10) | 0.120 | 0.72 (0.41–1.24) | 0.249 |
| Dominant model | 1.05 (0.49–2.62) | 0.905 | 1.43 (0.59–4.02) | 0.463 | 1.29 (0.80–2.15) | 0.313 | 1.24 (0.75–2.13) | 0.421 | |||
| Recessive model | 0.52 (0.28–0.94) | 0.034 | 0.63 (0.32–1.19) | 0.160 | 0.82 (0.59–1.13) | 0.221 | 0.87 (0.62–1.24) | 0.446 | |||
| Additive model | 1.92 (1.07–3.59) | 0.034 | 1.60 (0.84–3.12) | 0.160 | 1.22 (0.89–1.69) | 0.221 | 1.14 (0.81–1.62) | 0.446 | |||
Bold type indicates p < 0.05. Abbreviations: MA, migraine with aura; MO, Migraine without aura. ORadj (95% CI) adjusted factors: age, sex, BMI, marital status, nationality, educational level, smoking, alcohol, exercise, history of hypertension, history of diabetes, family history of diabetes, family history of migraine, SAS grade, PHQ9 grade, PSQI grade.
SLC17A8, solute carrier family 17 member 8; SHANK1, SH3 and multiple ankyrin repeat domains 1; TRPV1, transient receptor potential cation channel subfamily V member 1; TRPV3, transient receptor potential cation channel subfamily V member 3; TRPM8, transient receptor potential cation channel subfamily M member 8.